Publications associées à Chemical specificity

Recording physiological history of cells with chemical labeling

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

Amer Assoc Advancement Science2024

Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants

Kristin Schirmer, Juliane Hollender

Aquatic ecosystems continue to be threatened by chemical pollution. To what extent organisms are able to cope with chemical exposure depends on their ability to display mechanisms of defense across different organs. Among these mechanisms, biotransformatio ...

Elsevier2024

Membrane specificity of the human cholesterol transfer protein STARD4

Charlotte Julie Caroline Gehin

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Academic Press Ltd- Elsevier Science Ltd2024

De novo designed proteins: a study in engineering novel folds and functions

Alexandra Krina Van Hall-Beauvais

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

EPFL2023

A general strategy to develop fluorogenic polymethine dyes for bioimaging

Pablo Rivera Fuentes, Annabell Martin

Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development of advanced fluorogenic probes that reach intracellular targets and label them with high specificity. Excellent fluorogenic rhodamine d ...

Berlin2023

A molecular device for the redox quality control of GroEL/ES substrates

Camille Véronique Bernadette Goemans

Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial questions regarding how these ...

2023

A Sprayable Electrically Conductive Edible Coating for Piezoresistive Strain Sensing

Dario Floreano, Bokeon Kwak, Pietro Rossi

Edible electronics leverages the electronic properties of food-derived materials to deliver safer technologies that can be degraded (or digested) in the environment (or body) at the end-of-life. Sensors will be central to future smart edible robots, and ed ...

2023

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins

Anne-Florence Raphaëlle Bitbol

Author summaryWhen two protein families interact, their sequences feature statistical dependencies. First, interacting proteins tend to share a common evolutionary history. Second, maintaining structure and interactions through the course of evolution yiel ...

PUBLIC LIBRARY SCIENCE2023

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Chemical specificity

Recording physiological history of cells with chemical labeling

Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants

Membrane specificity of the human cholesterol transfer protein STARD4

Revealing chromatin-specific functions of histone deacylases

Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7

De novo designed proteins: a study in engineering novel folds and functions

A general strategy to develop fluorogenic polymethine dyes for bioimaging

A molecular device for the redox quality control of GroEL/ES substrates

A Sprayable Electrically Conductive Edible Coating for Piezoresistive Strain Sensing

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins

Graph Chatbot

Chattez avec Graph Search

Recording physiological history of cells with chemical labeling

A general strategy to develop fluorogenic polymethine dyes for bioimaging

A molecular device for the redox quality control of GroEL/ES substrates

Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins

Revealing chromatin-specific functions of histone deacylases

Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7

De novo designed proteins: a study in engineering novel folds and functions

A Sprayable Electrically Conductive Edible Coating for Piezoresistive Strain Sensing

Membrane specificity of the human cholesterol transfer protein STARD4