Concept
Chemical specificity
Publications associées (129)
Recording physiological history of cells with chemical labeling
Kai Johnsson, Julien Hiblot, Ling Hai
Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...
Amer Assoc Advancement Science2024Membrane specificity of the human cholesterol transfer protein STARD4
Charlotte Julie Caroline Gehin
STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...
Academic Press Ltd- Elsevier Science Ltd2024Revealing chromatin-specific functions of histone deacylases
Beat Fierz, Carlos Moreno Yruela
Histone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in v ...
2024Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7
The sirtuins are NAD+-dependent lysine deacylases, comprising seven isoforms (SIRT1-7) in humans, which are involved in the regulation of a plethora of biological processes, including gene expression and metabolism. The sirtuins share a common hydrolytic m ...
Weinheim2023De novo designed proteins: a study in engineering novel folds and functions
Alexandra Krina Van Hall-Beauvais
Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...
EPFL2023A general strategy to develop fluorogenic polymethine dyes for bioimaging
Pablo Rivera Fuentes, Annabell Martin
Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development of advanced fluorogenic probes that reach intracellular targets and label them with high specificity. Excellent fluorogenic rhodamine d ...
Berlin2023A molecular device for the redox quality control of GroEL/ES substrates
Camille Véronique Bernadette Goemans
Hsp60 chaperonins and their Hsp10 cofactors assist protein folding in all living cells, constituting the paradigmatic example of molecular chaperones. Despite extensive investigations of their structure and mechanism, crucial questions regarding how these ...
2023A Sprayable Electrically Conductive Edible Coating for Piezoresistive Strain Sensing
Dario Floreano, Bokeon Kwak, Pietro Rossi
Edible electronics leverages the electronic properties of food-derived materials to deliver safer technologies that can be degraded (or digested) in the environment (or body) at the end-of-life. Sensors will be central to future smart edible robots, and ed ...
2023