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Publications associées (31)
Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...
AMER ASSOC ADVANCEMENT SCIENCE2023How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior
The bacterium Vibrio cholerae is the causative agent of the diarrheal disease cholera, which affects millions of people every year. Apart from being a human pathogen, V. cholerae is also a common member of aquatic habitats. Whilst the mechanism that allow ...
EPFL2022Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset
Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide associa ...
FRONTIERS MEDIA SA2022Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link
Jacques Fellay, Christian Axel Wandall Thorball
Background: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs' e ...
ELIFE SCIENCES PUBLICATIONS LTD2021Spatial areas of genotype probability: Predicting the spatial distribution of adaptive genetic variants under future climatic conditions
Stéphane Joost, Oliver Michele Selmoni, Estelle Rochat
In a context of rapid global change, one of the key components for the survival of species is their genetic evolutionary potential for adaptation. Many methods have been developed to identify genetic variants underpinning adaptation to climate, but few too ...
WILEY2021The genetic architecture of complex human traits at the dawn of genomic medicine
The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine.
The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...
EPFL2021Automated phenotyping of Caenorhabditis elegans embryos with a high-throughput-screening microfluidic platform
Martinus Gijs, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Baris Atakan, Tunç Alkanat
The nematode Caenorhabditis elegans has been extensively used as a model multicellular organism to study the influence of osmotic stress conditions and the toxicity of chemical compounds on developmental and motility-associated phenotypes. However, the sev ...
2020Comprehensive analysis of PM20D1 QTL in Alzheimer's disease
Johannes Gräff, Liliane Glauser, Jose Vicente Sanchez Mut
Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...
BMC2020Feature Learning of Virus Genome Evolution With the Nucleotide Skip-Gram Neural Network
Recent studies reveal that even the smallest genomes such as viruses evolve through complex and stochastic processes, and the assumption of independent alleles is not valid in most applications. Advances in sequencing technologies produce multiple time-poi ...
2019Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia
DDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive processing speed (PS). First, following a case-control design (Study ...
2019