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Publications associées (56)
Intercellular calcium dynamics in smooth muscle cells
Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...
EPFL2009The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar
Yann Barrandon, Lukas Kappenberger, Hans-Anton Lehr
Objective: The MRL mouse strain shows extraordinary wound healing capacities. Some years ago, Leferovich et al. (Proc Natl Acad Sci U. S. A. 2001;98:9830-35) have reported the absence of scar formation after cryogenically-induced right ventricular myocardi ...
Elsevier2008Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions
Jean-Jacques Meister, Roger Sauser, Jean-Louis Bény, Michèle Koenigsberger, Dominique Seppey
In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...
2008Modeling the effects of dispersion and pulsatility of blood flow in pulsed arterial spin labeling
Arterial spin labeling (ASL) is a method of using MRI to image cerebral perfusion. For the measurement to be calibrated, a model is required describing the kinetics of the flow of the inverted blood from the labeling region to the imaging region. It is com ...
Wiley-Blackwell2008Myocardial perfusion assessment by use of system identification method in a one-compartment model
Philippe Thévenaz, Michel Kocher
Cardiovascular magnetic resonance has been shown to provide high data quality for myocardial perfusion assessment However, to analyze the perfusion data, some signal processing and modeling is needed to correct for motion related artifacts and limited spat ...
Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2007Myocardial Perfusion Assessment by Use of System Identification Method in a One-Compartment Model
Philippe Thévenaz, Michel Kocher
Cardiovascular magnetic resonance has been shown to provide high data quality for myocardial perfusion assessment. However, to analyze the perfusion data, some signal processing and modeling is needed to correct for motion related artifacts and limited spa ...
IEEE2007The effect of a myocardial infarction on the normalized time-varying elastance curve
Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger
It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Da ...
2006Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins
OBJECTIVE: Besides its predictive role in determining cardiovascular risk, C-reactive protein (CRP) may exert direct proatherogenic effects through proinflammatory properties. CRP is mainly produced by hepatocytes in response to interleukin-6 (IL-6) and is ...
2005A constitutive formulation of arterial mechanics including vascular smooth muscle tone
Nikolaos Stergiopoulos, Martin Zulliger, Alexander Rachev
A pseudo-strain energy function (pseudo-SEF) describing the biomechanical properties of large conduit arteries under the influence of vascular smooth muscle (VSM) tone is proposed. In contrast to previous models that include the effects of smooth muscle co ...
2004Automated Parameterization and Patching of Bifurcating Vessels
Recent developments in computational modeling of human arteries have opened the possibility of performing subject-specific analyses on increasingly larger numbers of subjects. This achievement will eventually lead to a better understanding of the role of g ...
2003