Concept
Évérolimus
Publications associées (9)
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial
PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...
2023An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX
Here we provide a personal account of innovation and design principles underpinning a method to interrogate precision electrophile signaling that has come to be known as "REX technologies". This Account is framed in the context of trying to improve methods ...
AMER CHEMICAL SOC2021Akt Is S-Palmitoylated: A New Layer of Regulation for Akt
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have ...
FRONTIERS MEDIA SA2021Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner
Freddy Radtke, Stefanie Siegert, Floriane Auderset
Th17 cells play critical roles in host defense and autoimmunity. Emerging data support a role for Notch signaling in Th17 cell differentiation but whether it is a positive or negative regulator remains unclear. We report here that T cell-specific deletion ...
Nature Publishing Group2016Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
Background: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer t ...
Biomed Central Ltd2016Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
New anticancer drugs that target oncogenic signaling molecules have greatly improved the treatment of certain cancers. However, resistance to targeted therapeutics is a major clinical problem and the redundancy of oncogenic signaling pathways provides back ...
2011Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling
Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marro ...
2011Dynamic modeling of the TOR signaling pathway in yeast
This Master thesis presents a complete cycle in the use of models for the study of a complex pathway like the TOR pathway. Previous models were reproduced for the phosphatase part of the pathway, and the assumptions used and the results they provided were ...
2009Syntheses of Stable Alpha-Silyloxyepoxides and Alpha-Chloroalkyl Silyl Ethers Derivatives of 3,10-Dioxa-5-Azatricyclo[5.2.1.0/2,6]Dec-4-Enes
The Diels-Alder adduct (+/-)-5 of furan to 1-cyanovinyl acetate was converted to (1RS,2RS,6RS,7SR,8SR,10RS)-10-)[(tert-butyl)dimethylsilyl]-oxy}-4-ethoox y (1) and -4-phenyl-3,9,11-trioxa-5-azatetracyclo[5.3.1.0(2,6).0(8,10)]-undec-4-en e (2). These compou ...
1994