Concept
Glucocorticoïde
Publications associées (89)
Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Sophie Elizabeth Walker, Silvia Monari
Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...
2023Glucocorticoid-based pharmacotherapies preventing PTSD
Maria del Carmen Sandi Perez, Silvia Monari
Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...
PERGAMON-ELSEVIER SCIENCE LTD2023Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study
Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...
EPFL2022Identification of biopsychological trait markers in functional neurological disorders
Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...
OXFORD UNIV PRESS2022Extended gate field-effect-transistor for sensing cortisol stress hormone
Mihai Adrian Ionescu, Junrui Zhang, Sadegh Kamaei Bahmaei, Hoël Maxime Guérin, Luca Capua, Shokoofeh Sheibani, Sayedeh Shirin Afyouni Akbari
Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect tr ...
SPRINGERNATURE2021LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance
Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq, Roman Moreno Fernandez
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...
2020Are Pre-ascent Low-Altitude Saliva Cortisol Levels Related to the Subsequent Acute Mountain Sickness Score? Observations from a Field Study
Background: The associations among cortisol levels, body water status, and acute mountain sickness (AMS) remain unclear. We investigated associations between AMS prevalence and severity with resting saliva cortisol levels at low altitude (LA) and high alti ...
MARY ANN LIEBERT, INC2019Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Stamatina Tzanoulinou, Orbicia Riccio Wicht, Vandana Veenit
Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...
2019Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Frédéric Bruno Martin Gachon, Benjamin Dieter Weger
The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...
CELL PRESS2019Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses
Maria del Carmen Sandi Perez, Jocelin Grosse, Damien Sébastien Huzard, Sriparna Ghosal
The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...
2019