Concept

Mushroom bodies

Publications associées (33)

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord. We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell li ...

Nature Publishing Group2013

How learning to shake a rattle affects 8-month-old infants' perception of the rattle's sound: Electrophysiological evidence for action-effect binding in infancy

Michiel van Elk

Bidirectional action-effect associations play a fundamental role in intentional action control and the development of the mirror neuron system. However, it has been questioned if infants are able to acquire bidirectional action-effect associations (i.e., a ...

Elsevier Sci Ltd2012

Maturation of Spinal Motor Neurons Derived from Human Embryonic Stem Cells

Our understanding of motor neuron biology in humans is derived mainly from investigation of human postmortem tissue and more indirectly from live animal models such as rodents. Thus generation of motor neurons from human embryonic stem cells and human indu ...

2012

Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries

Grégoire Courtine, Pavel Musienko, Rubia van den Brand

Descending monoaminergic inputs markedly influence spinal locomotor circuits, but the functional relationships between specific receptors and the control of walking behavior remain poorly understood. To identify these interactions, we manipulated serotoner ...

2011

Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems

Pavan P Ramdya

To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown ...

2011

Microfluidic hydrogel layers with multiple gradients to stimulate and perfuse three-dimensional neuronal cell cultures

Philippe Renaud, Arnaud Bertsch, Michele Giugliano, Anja Kunze

We present a simple and easy to handle PDMS microfluidic device for neuronal cell culture studies in three-dimensional hydrogel scaffolds. The hydrogel is structured in parallel layers to reconstruct cell layers close to the natural environment. Dissociate ...

Elsevier2009

Spontaneous locally restricted EEG alpha activity determines cortical excitability in the motor cortex

Friedhelm Christoph Hummel

There is growing interest in the functional meaning of rhythmical brain activity. For oscillatory brain activity around 10 Hz in the human electroencephalogram (EEG) it is discussed whether it is associated with the level of cortical excitation. However, i ...

Elsevier2009

Fixing the location and dimensions of functional neocortical columns

Henry Markram

The quest to understand the way in which neurons interconnect to form circuits that function as a unit began when Ramon y Cajal concluded that axo-dendritic apposition were too conspicuous to be incidental and proposed that two neurons must be communicatin ...

2008

A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data

Henry Markram, Idan Segev

We present a novel framework for automatically constraining parameters of compartmental models of neurons, given a large set of experimentally-measured responses of these neurons. In experiments, intrinsic noise gives rise to a large variability (e.g., in ...

2007

Optic-flow-based Altitude and Forward Speed Regulation using Stereotypical Lateral Movements

Dario Floreano, Jean-Christophe Zufferey, Antoine Beyeler

We propose a novel optic-flow-based flight control strategy, inspired by recent observations and hypothesis by Baird (unpublished), to regulate independently forward speed and altitude. Unlike previous approaches where longitudinal ventral optic flow was u ...

2007

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