Concept
Endothélium
Publications associées (156)
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal
Microvascular stalling, the process occurring when a capillary temporarily loses perfusion, has gained increasing interest in recent years through its demonstrated presence in various neuropathologies. Studying the impact of such stalls on the surrounding ...
2023Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea
Alessio Mylonas, Yichen Wang, Jiaqi Chen
Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...
AMER SOC CLINICAL INVESTIGATION INC2023Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization
Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer
Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...
FRONTIERS MEDIA SA2022The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Andrea Ablasser, Muhammet Fatih Gülen, Vivek Vijay Thacker, Théo Nass, Martin Schaller, Kunal Sharma
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5). Although rapid induction of type I ...
2022A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle
Bart Deplancke, Julie Marie Russeil, Sonia Karaz, Maria Deak, Umji Lee, Benjamin D. Cosgrove
Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and meta-bolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel regulator ...
CELL PRESS2022The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner
Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the ...
CELL PRESS2021