Concept

Vitamine A

Publications associées (35)

Vitamin D and energy homeostasis-of mice and men

Johan Auwerx, Kristina Schoonjans, Alessia Perino

The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...

Nature Publishing Group2014

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

Johan Auwerx, Evan Graehl Williams

Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-related ...

Elsevier2014

Multi-injection microstructured reactor for intensification of fast exothermic reactions: proof of concept

Albert Renken, Lioubov Kiwi, Thomas Maeder, Bo Jiang, Julien Haber

Quasi-instantaneous exothermic reactions lead to the formation of unwanted hot spots even when carried out in conventional microstructured reactors (MSR) with tube diameter of 100 − 1000 μm. For this reason, alternative MSR designs are warranted to enable ...

Walter de Gruyter2013

A vitamin B-12 transporter in Mycobacterium tuberculosis

John McKinney

Vitamin B-12-depende enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B-12 in vitro, it is uncertain whether the org ...

Royal Society, The2013

Microalgal carotenoid recovery in a biorefinery approach

Christof Holliger, Christian Ludwig, Jean-Paul Schwitzguebel, Mariluz Bagnoud, Olivier Laurent Emery

Introduction Microalgae culture to be effective as feedstock for bio-energy production needs to overcome constraining biotechnological, technological and economic factors [1]. In order to establish an economically viable process, the co-production of renew ...

2012

Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism

Freddy Radtke, Yann Barrandon

Integrity and preservation of a transparent cornea are essential for good vision. The corneal epithelium is stratified and nonkeratinized and is maintained and repaired by corneal stem cells. Here we demonstrate that Notch1 signaling is essential for cell ...

2007

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary lipids. By using targeted somatic mutagenesis of the nuclear receptor liver receptor homolog 1 (LRH-1) in mouse hepatocytes, w ...

2007

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells

Johan Auwerx

We show that mice expressing retinoid X receptor beta (RXRbeta) impaired in its transcriptional activation function AF-2 (Rxrb(af20) mutation) do not display the spermatid release defects observed in RXRbeta-null mutants, indicating that the role of RXRbet ...

2004

Early Steps of the Intramolecular Signal Transduction in Rhodopsin Explored by Molecular Dynamics Simulations

Ursula Röthlisberger, Leonardo Guidoni

We present mol. dynamics simulations of bovine rhodopsin in a membrane mimetic environment based on the recently refined x-ray structure of the pigment. The interactions between the protonated Schiff base and the protein moiety are explored both with the c ...

2002

Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus

Freddy Radtke, Anne Wilson

We have recently reported that Notch 1, a member of the Notch multigene family, is essential for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated in bone marrow (BM) precursors we have shown that B cells instead of T c ...

2001

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