List of progestogen esters

This is a list of progestogen esters, or esters of progestogens. Unlike the case of testosterone and estradiol, progesterone cannot be esterified as it lacks hydroxyl groups, so all progestogen esters, with the exception of esters of 17α-hydroxyprogesterone like hydroxyprogesterone caproate, are esters of progestins (synthetic progestogens) and are non-bioidentical. In addition, whereas all androgen and estrogen esters are prodrugs of the parent compound, only some and not all progestogen esters act as prodrugs. Esters of 17α-hydroxyprogesterone and 19-norprogesterone derivatives like hydroxyprogesterone caproate, medroxyprogesterone acetate, and nomegestrol acetate are active themselves and are not prodrugs, whereas esters of 19-nortestosterone derivatives like norethisterone acetate and norethisterone enanthate are not active themselves and are prodrugs. The following major progestogen esters have been marketed: Chlormadinone acetate (Prostal, Belara) Cyproterone acetate (Androcur, Cyprostat, Diane, Diane-35) Hydroxyprogesterone caproate (Proluton, Proluton Depot, Makena; Delalutin) Medroxyprogesterone acetate (Depo-Provera, Provera) Megestrol acetate (Megace) And the following minor progestogen esters have been marketed: Acetomepregenol (mepregenol diacete; Diamol) Anagestone acetate (Anatropin; ORF-1658) Chlormethenmadinone acetate (Biogest, Agelin) Flumedroxone acetate (Demigran, Leomigran; WG-537) Hydroxyprogesterone acetate (acetoxyprogesterone; Prodox) Hydroxyprogesterone heptanoate (H.O.P., Lutogil A.P., Lutogyl A.P.) Methenmadinone acetate (Superlutin, Antigest) Pentagestrone acetate (Gestovis, Gestovister) The following veterinary-only progestogen esters have also been marketed: Delmadinone acetate (Tardak) Flugestone acetate (Chronogest, Chrono-Gest, Cronolone, Synchro-Mate, Gyncro-Mate; NSC-65411, SC-9880) Melengestrol acetate (Heifermax, MGA) Osaterone acetate (Ypozane; TZP-4238) The corticosteroid ester mometasone furoate (Asmanex, Elocom, Elocon, Elosalic, Nasonex), which is a 17α-hydroxyprogesterone derivative, also has very potent progestogenic activity, though it is not used as a progestogen and is instead used exclusively as a corticosteroid.