Publications associées à Récepteur de type Toll

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Dectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses. Identifying pathogen ligands and underst ...

NATURE PUBLISHING GROUP2018

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

Bruno Lemaitre, Samuel Rommelaere, Anna Dostalova

Background: Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the role of TEPs in Drosophila immun ...

2017

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Alessandra Piersigilli, Julie Deuquet Ariosa, Jérôme Bürgi

Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and ...

Springer Nature2017

Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

Kristin Schirmer, Anita Orsolya Hidasi

Synthetic glucocorticoids (GCs) are potential endocrine disrupting compounds that have been detected in the aquatic environment around the world in the low ng/L (nanomolar) range. GCs are used as immunosuppressants in medicine. It is of high interest wheth ...

Elsevier2017

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Andrea Ablasser, Ute Koch, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Johan Auwerx, Tytti Heinonen

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been ...

Nature Publishing Group2017

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

Johan Auwerx, Kristina Schoonjans, Xu Wang

The plasma membrane-bound G protein-coupled bile acid receptor (TGR5) displays varied levels of expression in different tissues. TGR5-induced liver protection has been demonstrated during several liver diseases, except during ischemia/reperfusion injury (I ...

Wiley2017

De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria

Inmaculada Rentero Rebollo

Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides. Specif ...

Royal Soc Chemistry2017

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Récepteur de type Toll

Podosomes, But not the Maturation status, Determine the Protease-Dependent 3D Migration in human Dendritic cells

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

Signalling strength determines proapoptotic functions of STING

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish

De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria

Graph Chatbot

Chattez avec Graph Search

Signalling strength determines proapoptotic functions of STING

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria

Podosomes, But not the Maturation status, Determine the Protease-Dependent 3D Migration in human Dendritic cells

Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections