Concept

Arthrite septique

Publications associées (39)

Comparison of Muscle Coordination in Two Patient Specific Shoulder Models

The shoulder provides mobility to the upper limb and is thus necessary for lots of activities. Consequently injuries in the shoulder joint affect the patient in his daily life. The study of shoulder pathologies is however difficult : each patient has his i ...

2015

Design and integration of an instrumented knee prosthesis

Matteo Simoncini

Total knee arthroplasty is nowadays one of the most important orthopedic surgery. It consists of a procedure in which parts of the knee are replaced by a prosthesis. The largest indication for total knee arthroplasty is osteoarthritis, a knee disease that ...

EPFL2014

Role and regulation of the melanization reaction in Drosophila immune response

Olivier Binggeli

In arthropods, the melanization reaction consists in the rapid synthesis of melanin at the site of infection and injury. A key enzyme in the melanization process is phenoloxidase (PO), which catalyzes the oxidation of phenols to quinones that subsequently ...

EPFL2013

Design and test of a MEMS strain-sensing device for monitoring artificial knee implants

Kamiar Aminian, Philippe Renaud, Alexandre Terrier, Arnaud Bertsch, Arash Arami, Willyan Hasenkamp Carreira

This paper describes the development of a polyimide-based MEMS strain-sensing device. Finite element analysis was used to investigate an artificial knee implant and assist on device design and to optimize sensing characteristics. The sensing element of the ...

Springer2013

A vitamin B-12 transporter in Mycobacterium tuberculosis

John McKinney

Vitamin B-12-depende enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B-12 in vitro, it is uncertain whether the org ...

Royal Society, The2013

Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis

Hubert van den Bergh

We have developed a thrombin-sensitive polymeric photosensitizer prodrug (T-PS) to selectively image and eradicate inflammatory lesions in rheumatoid arthritis (RA). Thrombin is a serine protease up-regulated in synovial tissues of rheumatoid arthritis (RA ...

Elsevier2012

Simulation of total ankle replacement using numerical modeling

Sara Molins Cabaní

The ankle is a complex joint of the human body which is most often affected by trauma. Osteoarthritis is a joint disease that can require surgical intervention and when it affects the ankle there are two options to achieve pain relief. For years ankle fusi ...

2012

Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints

Georges Wagnières, Jutta Christine Wandrey, Frédéric Schmitt, Jérôme Barge, Lucienne Lagopoulos

Macrophages play key roles in inflammatory disorders. Therefore, they are targets of treatments aiming at their local destruction in inflammation sites. However, injection of low molecular mass therapeutics, including photosensitizers, in inflamed joints r ...

Elsevier2010

Trans-cis-cis-[RuCl2(DMSO)(2)(2-amino-5-methyl-thiazole)(2)], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B

Angela Casini

A novel ruthenium(II) compound, trans-cis-cis-[Ru(II)Cl-2(DMSO)(2)(2-amino-5-methyl-thiazole)(2)], (I), PMRu52 hereafter, that may be obtained from the previously described (cis and trans)[Ru(II)Cl-2(DMSO)(4)] complexes, was designed, synthesized and chara ...

2010

Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

Bruno Lemaitre, David Welchman

The systemic immune response of Drosophila is known to be induced both by septic injury and by oral infection with certain bacteria, and is characterized by the secretion of antimicrobial peptides (AMPs) into the haemolymph. To investigate other possible r ...

2009

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