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Publications associées (32)

Cycloalkane Oxidation Catalyzed by Copper-based Catalysts with H2O2 under Mild Conditions

Copper-catalyzed cycloalkane oxidation using H2O2 as an oxidant was investigated under mild conditions. The copper catalysts studied in this work ranged from commercially-available copper(II) salts to copper(II) complexes containing polypyridyl ligands. Va ...

WILEY-V C H VERLAG GMBH2023

Mechanistic classification and benchmarking of polyolefin depolymerization over silica-alumina-based catalysts

Paul Joseph Dyson, Mounir Driss Mensi, Felix Daniel Bobbink, Antoine Philippe Van Muyden, Wei-Tse Lee, Jed Russell Carullo

Carbon-carbon bond cleavage mechanisms play a key role in the selective deconstruction of alkanes and polyolefins. Here, we show that the product distribution, which encompasses carbon range and formation of unsaturated and isomerization products, serves a ...

2022

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5

Maurizio Molinari

The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formation, isomerization ...

2020

Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase

Xile Hu, Farzaneh Fadaei Tirani, Matthew Wodrich, Huijie Pan, Renyi Shi

A novel nickel pincer cofactor was recently discovered in lactate racemase. Reported here are three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ip ...

WILEY-V C H VERLAG GMBH2019

Site-selective Synthesis of -[70]PCBM-like Fullerenes: Efficient Application in Perovskite Solar Cells

Michael Graetzel, Shaik Mohammed Zakeeruddin, Jiyoun Seo, Seckin Akin

We report on the site-selective synthesis of PCBM-like [70]fullerene site-isomers, where the elusive -site-isomers are, for the first time, the major product in a (cyclo)addition chemical reaction involving [70]fullerene. The reaction involves an straightf ...

WILEY-V C H VERLAG GMBH2019

Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer

Rosario Scopelliti, Xile Hu, Matthew Wodrich, Tao Xu

Pincer complexes are widely applied in homogeneous catalysis. However, only very recently has the first pincer complex been discovered in the active site of a metalloenzyme, namely, lactate racemase. Here, we report a synthetic model of the active site of ...

Natl Acad Sciences2017

Natural inspirations for metal–ligand cooperative catalysis

Xile Hu, Matthew Wodrich

In conventional homogeneous catalysis, supporting ligands act as spectators that do not interact directly with substrates. However, in metal–ligand cooperative catalysis, ligands are involved in facilitating reaction pathways that would be less favourable ...

2017

Natural inspirations for metal–ligand cooperative catalysis

Xile Hu, Matthew Wodrich

2017

A Novel Nickel Pincer Complex in the Active Site of Lactate Racemase

Xile Hu, Gerald Bauer, Tao Xu

A recent study revealed the structure of the Ni-containing active site of lactate racemase. The Ni is coordinated by a SCS pincer ligand derived from a nicotinic acid mononucleotide. ...

Wiley-Blackwell2016

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