Concept
Efflux
Publications associées (18)
Homogeneous vs. heterogeneous photo-Fenton elimination of antibiotic-resistant bacteria bearing intracellular or extracellular resistance: Do resistance mechanisms interfere with disinfection pathways?
César Pulgarin, Stefanos Giannakis, Truong-Thien Melvin Le, Jérémie Decker
The present study aimed to fill the knowledge gap between the implications of intracellular and extracellular antibiotic resistance mechanisms may inflict on the inactivation pathways of the photo-Fenton process under mild conditions. It was thus designed ...
London2024A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading microbes. These short immune effectors are conserved in plants, animals, and fungi. Early work showed that AMPs killed bacteria in generalist fashions in vitro: i.e. AMPs that ...
EPFL2022Variability in arsenic methylation efficiency across aerobic and anaerobic microorganisms
Rizlan Bernier-Latmani, Karin Lederballe Meibom, Karen Elda Viacava Romo, Arnaud Michel Gelb, Leia Soraya Véronique Falquet, Shannon Eliot Dyer, Adrien Mestrot
Microbially-mediated methylation of arsenic (As) plays an important role in the As biogeochemical cycle, particularly in rice paddy soils where methylated As, generated microbially, is translocated into rice grains. The presence of the arsenite (As(III)) m ...
2020Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM ...
Proceedings of the National Academy of Sciences2018Mechanistic insight into mycobacterial MmpL protein function
Stewart Cole, Edina Rita Székely
Mycobacterial cell walls are complex structures containing a broad range of unusual lipids, glycolipids and other polymers, some of which act as immunomodulators or virulence determinants. Better understanding of the enzymes involved in export processes wo ...
Wiley-Blackwell2016Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus
Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay
Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation- ...
Nature Publishing Group2016