Concept
De novo synthesis
Publications associées (26)
Recycling of Polymerase Chain Reaction (PCR) Kits
Francesco Stellacci, Weina Liu, Yong Zhu
Polymerase chain reaction (PCR) kits have been used as common diagnosing tools during the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with daily worldwide usage in the millions. It is well known that at the beginn ...
AMER CHEMICAL SOC2023Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease
Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram
Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...
2021A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives
Vassily Hatzimanikatis, Jasmin Maria Hafner
Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...
NATURE RESEARCH2021Computational studies of industrial hosts for improved production of the 2nd generation of biofuels
In an effort of overcoming the limited availability of fossil energy resources and moving toward a sustainable economy, the focus of the research and development in the area of biofuels has shifted towards developing the 2nd generation of fuels that should ...
EPFL2019N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health
N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...
FEDERATION AMER SOC EXP BIOL2019Renal metabolism of hyperpolarized [1-13C]aspartate
Hikari Ananda Infinity Yoshihara
Aspartic acid is involved in several central metabolic pathways, including gluconeogenesis, the urea cycle, de novo nucleotide synthesis, the malate-aspartate shuttle, and via transmination the TCA cycle. The conversion in vivo of hyperpolarized [1-13C]pyr ...
2018Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism
Benjamin Dieter Weger, Meltem Weger
Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficienc ...
2018Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver X Receptors (LXRs) play an important role owing to their ability to reduce cellular cholesterol l ...
2017Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences
Vassily Hatzimanikatis, Homa Mohammadi Peyhani, Noushin Hadadi
A key challenge in metabolic engineering is to design novel or to improve existing biosynthetic pathways that lead to the cellular production of a given industrial or pharmaceutical compound. In many cases, the required enzymatic reactions for the biosynth ...
2017Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways
Vassily Hatzimanikatis, Noushin Hadadi
Designing putative metabolic pathways is of great interest in synthetic biology. Retrobiosynthesis is a discipline that involves the design, evaluation, and optimization of de novo biosynthetic pathways for the production of high-value compounds and drugs ...
Elsevier Sci Ltd2015