Publications associées à Lesional demyelinations of the central nervous system

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

Veronica Lily Ravano

Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

EPFL2024

Accurate Diagnosis of Cortical and Infratentorial Lesions in Multiple Sclerosis Using Accelerated Fluid and White Matter Suppression Imaging

Tobias Kober

Objectives: The precise location of multiple sclerosis (MS) cortical lesions can be very challenging at 3 T, yet distinguishing them from subcortical lesions is essential for the diagnosis and prognosis of the disease. Compressed sensing-accelerated fluid ...

LIPPINCOTT WILLIAMS & WILKINS2023

Streamline RimNet: Tools for Automatic Classification of Paramagnetic Rim Lesions in MRI of Multiple Sclerosis

Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

This site provides two software tools related to "RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis" by Barquero et al. NeuroImage: Clinical (2020). People using in part or f ...

Zenodo2023

A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients

Meritxell Bach Cuadra, Tobias Kober, Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez, Cristina Granziera, Muhamed Barakovic, Lester Melie Garcia, Po-Jui Lu

BackgroundDetecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan-PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assesses new and enlarge ...

WILEY2023

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

Alexey Sapozhnik, Samuel Jones

JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...

Amer Soc Microbiology2023

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

Erick Jorge Canales Rodriguez, Marco Pizzolato, Tim Bjørn Dyrby

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherica ...

ELSEVIER2023

Deep learning-based analysis of multiple sclerosis lesions with high and ultra-high field MRI

Francesco La Rosa

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and affects almost 3 million people worldwide. There is currently no cure for MS, and its symptoms, starting with fatigue and weakness, often progress over time ...

EPFL2022

Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Francesco La Rosa, Cristina Granziera, Maxence Charles F Wynen

The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progres ...

ELSEVIER SCI LTD2022

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Jordan Squair

Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity in ...

2021