Concept

Myocyte

Publications associées (331)

Long-term culture and high-resolution imaging of C. elegans using an automated microfluidic platform

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Govindan Narayanan Krishnamani

The nematode Caernohabditis elegans is one of the most employed small model organisms in biology. Studies on transgenic animals often require the accurate observation of highly localized fluorescent signals inside the worms at high magnification, hence dem ...

2015

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...

American Diabetes Association2015

Development of Implantable Electrodes Based on Polymer Derived Ceramics

Jonas Grossenbacher

The invention of heart pacemakers in the 50's aims to help patients to overcome heart strokes, which represent the first cause of death worldwide. In Europe and in the USA, more than 3000 pacemakers are implanted every day. Despite the constant evolution o ...

EPFL2015

Solvability analysis and numerical approximation of linearized cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier

This paper is concerned with the mathematical analysis of a coupled elliptic–parabolic system modeling the interaction between the propagation of electric potential and subsequent deformation of the cardiac tissue. The problem consists in a reaction–diffus ...

World Scientific Publ Co Pte Ltd2015

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Musculoskeletal Model of the Human Shoulder for Joint Force Estimation

David Ingram

Human beings like all organisms, are subject to a variety of diseases. Musculoskeletal diseases such as arthritis, that affect our muscles and bones, are particularly debilitating in that they considerably limit our ability to interact with our environment ...

EPFL2015

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Johan Auwerx, Norman Lionel Moullan, Nouria Hernandez, Gilles Willemin, Rajat Singh

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. H ...

Cold Spring Harbor Lab Press, Publications Dept2015

Decoding bipedal locomotion from the rat sensorimotor cortex

Silvestro Micera, Grégoire Courtine, Rubia van den Brand, Jacopo Rigosa, Lucia Florinda Friedli Wittler

Objective. Decoding forelimb movements from the firing activity of cortical neurons has been interfaced with robotic and prosthetic systems to replace lost upper limb functions in humans. Despite the potential of this approach to improve locomotion and fac ...

Institute of Physics2015

Generalization of motor resonance during the observation of hand, mouth, and eye movements

Michela Bassolino

Transcranial magnetic stimulation (TMS) of the motor cortex shows that hand action observation (AO) modulates corticospinal excitability (CSE). CSE modulation alternatively maps low-level kinematic characteristics or higher-level features, like object-dire ...

Amer Physiological Soc2015

Improved surface coil design and pulse sequence development for in vivo 13C MR spectroscopy of humans at 7T

Eulalia Serés Roig

Nuclear magnetic resonance (NMR) is a non-invasive tool for the study of human diseases. In particular, carbon-13 magnetic resonance spectroscopy (13C MRS) is a promising derivative tool for investigating metabolism in vivo, as it allows the non-invasive m ...

EPFL2015

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