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The goal of this thesis was to open a new route to the synthesis of conjugated trienes using a new SO2-based C-C bond forming reactions developed in Lausanne. In addition, the potential of SO2 for applications in synthetic organic chemistry has been exploi ...
Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present ...
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds that induce peroxisome proliferation. PPARgamma is the best characterized of the PPARs. The heterodimer of P ...
In this thesis, the synthesis of oligomers of β-amino acids (β-peptides) is described. Their secondary structure is investigated by several techniques, in particular nuclear magnetic resonance (NMR) spectroscopy, but also circular dichroism and infrared sp ...
The functional role of glutamate decarboxylase (GAD) and its product GABA in pancreatic islets has remained elusive. Mouse β-cells express the larger isoform GAD67, whereas human islets express only the smaller isoform GAD65. We have generated two lines of ...
Enantiomerically pure beta-amino acid derivs. with the side-chains of Ala, Val, and Leu in the 2- or 3-position (β2- and β3-amino acids, resp.), as well as with substituents in both the 2- and 3-positions (β2,3-amino acids, of like-configuration) were prep ...
Fluorescent proteins expressed in mammalian cells can be quantified quickly and noninvasively with a standard fluorescence plate reader. We have previously exploited this quality in cell growth assessment (Hunt et al., 1999b). In this work, different CHO c ...
We report on a study of B 0 → D(*)0 π+π- decays using 29.1 fb-1 of e+e- annihilation data recorded at the γ(4S) resonance with the Belle detector at the KEKB storage ring. Making no assumptions about the intermediate mechanism, the branching fractions for ...
Fatty acids play important biological roles in cells. The precise mechanism whereby fatty acids cross the plasma membrane is still poorly understood. They can cross membranes because of their hydrophobic properties and/or be transported by specific protein ...
The known solid-state structure of cyclo(β-HAla)4 was used to model the structure of the cyclo-β-tetrapeptide (β-HPhe-β-HThr-β-HLys-β-HTrp) as a prospective somatostatin mimic. The synthesis started with the N-protected natural amino acids Boc-Phe-OH, Boc- ...
