Publications associées à Héparine de bas poids moléculaire

MRI characterization of in vitro clots at 3T and 7T: A technical note

In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ...

Masson Editeur2024

Programmable DARPin-based receptors for the detection of thrombotic markers

Leo Scheller, Yujia Wang, Haifeng Ye

Cellular therapies remain constrained by the limited availability of sensors for disease markers. Here we present an integrated target-to-receptor pipeline for constructing a customizable advanced modular bispecific extracellular receptor (AMBER) that comb ...

NATURE PORTFOLIO2022

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Simon Jan Middendorp, Patrick Andreas Gonschorek, Christina Lamers

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

Nature Research2020

Carbohydrate stabilization extends the kinetic limits of chemical polysaccharide depolymerization

Jeremy Luterbacher, Masoud Talebi Amiri, Ydna Marie Questell-Santiago, Raquel Zambrano Varela

Polysaccharide depolymerization is an essential step for valorizing lignocellulosic biomass. In inexpensive systems such as pure water or dilute acid mixtures, carbohydrate monomer degradation rates exceed hemicellulose—and especially cellulose—depolymeriz ...

2018

Microdevice for Sedimentation-based Separation of Blood Microsamples at the Point of Collection

David Forchelet

Laboratory blood testing plays a central role in current diagnostics and therapeutical decisions. Thus, errors have a direct impact on care quality and cost. The majority of errors occur in the pre-analytical phase, when samples are collected, stored and p ...

EPFL2017

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Philippe Renaud, Lynda Metref

Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments gener ...

2012

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Kay Severin

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4'-methyl-2,2'-bipyri ...

Royal Society of Chemistry2010

Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

Jeffrey Alan Hubbell

The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems ...

2006

Coagulants of Moringa Oleifera Lam. seeds : purification & characterisation

Water has been declared a human right by the United Nations, thus urging countries who have ratified the International Covenant on Economic, Social and Cultural Rights to ensure supply with drinking water for their populations1. However, supply of drinking ...

EPFL2005

Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors

Didier Trono, Romain Zufferey

Lentiviral vectors represent an attractive technology platform from which to develop a targetable injectable gene delivery system for transduction of specific cell populations in vivo, irrespective of their cell cycle status. Targeted HIV-1-based lentivira ...

2001