Concept
Autocrine
Publications associées (177)
Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma
Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...
EPFL2023Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates
Freddy Radtke, Ute Koch, Catherine Michelle Hoffman
Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. To assess whether Notch's effects are evol ...
AMER ASSOC ADVANCEMENT SCIENCE2023Cancer hallmarks intersect with neuroscience in the tumor microenvironment
The mechanisms underlying the multistep process of tumorigenesis can be distilled into a logical framework involving the acquisition of functional capabilities, the so-called hallmarks of cancer, which are collectively envisaged to be necessary for maligna ...
CELL PRESS2023Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential
Lijing Xin, Kim Do, Daniella Dwir
Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia (SZ), bipolar d ...
OXFORD UNIV PRESS2023Tumor dormancy: EMT beyond invasion and metastasis
Cathrin Brisken, Hazel Margaret Quinn, Patrik Aouad
More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from ...
WILEY2023Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics
Sandrine Gerber, Jérémy Vuilleumier, Adrian Stefan Gheata, Dario Diviani, Luigi Bonacina, Simon Kaiser
Nanoparticle-based drug delivery systems have the potential for increasing the efficiency of chemotherapeutics by enhancing the drug accumulation at specific target sites, therebyreducing adverse side effects and mitigating patient acquired resistance. In ...
2022