Concept
Interleukine
Publications associées (127)
Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis
Freddy Radtke, Ute Koch, Jialin Zhang, Soufiane Boumahdi
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...
ELSEVIER2023PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells
Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni
Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...
NATURE PORTFOLIO2022Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation
Yimon Aye, Pierre Alexander Miranda Herrera
ABSTRACT: Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophile ...
AMER CHEMICAL SOC2022IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Interleukin-17A- (IL-17A) and IL-17F-producing CD4(+) T helper cells (T(H)17 cells) are implicated in the development of chronic inflammatory diseases, such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). T-H 17 ...
AMER ASSOC ADVANCEMENT SCIENCE2021De novo development of proteolytically resistant therapeutic peptides for oral administration
Christian Heinis, Luciano Andres Abriata, Florence Pojer, Xudong Kong, Vanessa Carle, Jun Moriya
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal pro ...
2020