Concept

Pharmacokinetics of estradiol

Publications associées (20)

Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?

Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globally, while other ...

Endocrine Soc2024

La lumière naturelle en milieu préscolaire. Nouvelle institution à Bussigny-Ouest

Marilyn Brühlmann

L’implantation du projet est prévue à l’Ouest de Bussigny, une commune de la périphérie Lausannoise en pleine évolution démographique. Il vient soulager la forte demande actuelle en places d’accueil préscolaire ainsi anticipe sur les scénarios moyens prévu ...

2022

Estrogen receptor signaling in the human breast epithelium

Céline Berthe Constantin

Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...

EPFL2022

A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

Cathrin Brisken, Jonathan Paz Montoya, Marc Moniatte, Fabio De Martino, Marie Shamseddin, Csaba Ferenc László, Alexandre Béguin

In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins bestows a breast cancer relative ri ...

2019

Development of a modified QuEChERS method for multi-class pesticide analysis in human hair by GC-MS and UPLC-MS/MS

Luiz Felippe De Alencastro, Edouard René Gilbert Lehmann, Christelle Oltramare

The present study assessed the suitability of using QuEChERS procedure for the simultaneous deter- mination and quantification of 37 multi-class pesticides in human hair. Matrix co-eluted material had a large influence on instrumental response sensitivity. ...

Elsevier2018

Rapid Production of Submicron Drug Substance Particles by Supersonic Spray Drying

Esther Amstad

Many newly developed active pharmaceutical ingredients (APIs) are poorly soluble in water and thus have a dissolution-limited bioavailability. The bioavailability of Biopharmaceutical Classification System (BCS) class II APIs increases if they dissolve fas ...

Amer Chemical Soc2017

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex

Johannes Gräff, Jose Vicente Sanchez Mut

The brain's neocortex is anatomically organized into grey and white matter, which are mainly composed by neuronal and glial cells, respectively. The neocortex can be further divided in different Brodmann areas according to their cytoarchitectural organizat ...

Wiley-Blackwell2017

Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

Stephane Kontos, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Alexandre de Titta, Iraklis Kourtis

Nanoparticles have been extensively developed for therapeutic and diagnostic applications. While the focus of nanoparticle trafficking in vivo has traditionally been on drug delivery and organ-level biodistribution and clearance, recent work in cancer biol ...

Public Library of Science2013

Bicyclization and tethering to albumin yields long-acting Peptide antagonists

Christian Heinis, Alessandro Angelini, Shiyu Chen, Philippe Diderich, Julia Morales Sanfrutos

Proteolytically stable peptide architectures are required for the development of long-acting peptide therapeutics. In this work, we found that a phage-selected bicyclic peptide antagonist exhibits an unusually high stability in vivo and subsequently deciph ...

Amer Chemical Soc2012

Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools

Julien Dusonchet

Animal models of human pathologies remain invaluable tools for unraveling disease mechanisms and evaluating potential therapeutic strategies. For a number of diseases, the lack of a reliable animal model represents an important limiting step towards the de ...

EPFL2010

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