Concept

Directional selection

Publications associées (182)

A cell fitness selection model for neuronal survival during development

Developmental cell death plays an important role in the construction of functional neural circuits. In vertebrates, the canonical view proposes a selection of the surviving neurons through stochastic competition for target-derived neurotrophic signals, imp ...

2019

Large-scale variational inference for Bayesian joint regression modelling of high-dimensional genetic data

Hélène Ruffieux

Genetic association studies have become increasingly important in understanding the molecular bases of complex human traits. The specific analysis of intermediate molecular traits, via quantitative trait locus (QTL) studies, has recently received much atte ...

EPFL2019

Quadruplet Selection Methods For Deep Embedding Learning

Erhan Gündogdu

Recognition of objects with subtle differences has been used in many practical applications, such as car model recognition and maritime vessel identification. For discrimination of the objects in fine-grained detail, we focus on deep embedding learning by ...

IEEE2019

MPA-SSA, design and test of a 65 nm ASIC-based system for particle tracking at HL-LHC featuring on-chip particle discrimination

Yusuf Leblebici, Alessandro Caratelli, Davide Ceresa, Simone Scarfì

Particle tracking detectors for High Energy Physics need a new readout technique to cope with the increase of the collision rate foreseen for the High Luminosity LHC upgrade. In particular, the selection of interesting physics events at the first trigger s ...

IEEE2019

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Hüseyin Baris Atakan

Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerational epigenetics is the defined term for such intergenerational transient inheritance without an alteration in the D ...

2019

A systematic review of machine learning methodologies for modelling passenger mode choice

Michel Bierlaire, Timothy Michael Hillel

Machine Learning (ML) approaches are increasingly being investigated as an alternative to Random Utility Models (RUMs) for modelling passenger mode choice. These approaches have the potential to provide valuable insights into choice modelling research ques ...

2019

Effect heterogeneity and variable selection for standardizing causal effects to a target population

Mats Julius Stensrud, Anders Huitfeldt

The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing resul ...

2019

MEMS Piezoelectric Accelerometer for Vibration Sensing in Harsh Environments

Bradley James Petkus

This master thesis presents a detailed overview of various MEMS accelerometers used as vibrometers in harsh environments. Commercial and scientific literature accelerometers are compared to determine the best accelerometer for said application. This compar ...

2019

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity

Jacques Fellay, Gabriel Leventhal

Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as" per-parasite pathogen ...

Oxford University Press2018

Signatures of selection and environmental adaptation across the goat genome post-domestication

Stéphane Joost, Estelle Rochat

Background: Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems and/or purposes and (ii) adaptation t ...

BMC2018

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