Concept

Tryptophane

Publications associées (39)

Microsolvation effects on the excited state dynamics of protonated tryptophan

Ursula Röthlisberger, Thomas Rizzo, Ivano Tavernelli, Michele Cascella, Sébastien Mercier, Matteo Guglielmi

To better understand the complex photophysics of the amino acid tryptophan, which is widely used as a probe of protein structure and dynamics, we have measured electronic spectra of protonated, gas-phase tryptophan solvated with a controlled number of wate ...

2006

Insights into excited-state and isomerization dynamics of bacteriorhodopsin from ultrafast transient UV absorption

Majed Chergui, Frank van Mourik, Selma Schenkl

A visible-pump/UV-probe transient absorption is used to characterize the ultrafast dynamics of bacteriorhodopsin with 80-fs time resoln. We identify three spectral components in the 265- to 310-nm region, related to the all-trans retinal, tryptophan (Trp)- ...

2006

Infrared photofragment spectroscopy of charged amino acid water clusters in the gas phase

Anthi Kamariotou

We present in this work a new technique, which combines laser photofragmentation spectroscopy with tandem mass spectrometry, for structural investigations of biomolecular ions in the gas phase. A novel apparatus was designed and built for the implementatio ...

EPFL2006

Electronic spectroscopy of cold, protonated tryptophan and tyrosine

Thomas Rizzo, Sébastien Mercier

We report here a new method to obtain electronic spectra of biomolecular ions that are produced in the gas phase by electrospray and cooled to ~10K in a 22-pole ion trap, and we demonstrate this technique by applying it to protonated tryptophan and tyrosin ...

2006

Influence of the protein environment on spectroscopy and ultrafast dynamics of retinal in bacteriorhodopsin

Selma Schenkl

The environment is important for the exact course of a chemical reaction. As an example of the strong influence of the environment on the reaction, this work studies the isomerization reaction of the chromophore retinal in the binding pocket of the protein ...

EPFL2004

Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis

Kai Johnsson, Claudio Arrivoli, Petra Tafelmeyer, Martin Wilming

Combinatorial mutagenesis was used to investigate the role of three key residues in cytochrome c peroxidase (CCP) from Saccharomyces cerevisiae, Arg48, Trp51, and Trp191, in control of the reactivity and selectivity of the heme-contg. enzyme. Libraries wer ...

2002

PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum

We have isolated a novel protein kinase cDNA, PfPK6, by differential display RT-PCR (DDRT-PCR) of mRNA obtained from different asexual erythrocytic stages of Plasmodium falciparum, which shows sequence similarity to both cyclin-dependent kinase (CDK) and m ...

Portland Press2000

LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine

Lukas Kühn, Bernard Sordat

Glycoprotein-associated amino acid transporters (gpaAT) are permease-related proteins that require heterodimerization to express their function. So far, four vertebrate gpaATs have been shown to associate with 4F2hc/CD98 for functional expression, whereas ...

1999

Synthesis and biological evaluation of a cyclo-β-tetrapeptide as a somatostatin analog

Karl Gademann

Cyclo-beta-tetrapeptide I, a beta-peptidic analog of octreotide, was prepd. from beta-amino acid building blocks synthesized by Arndt-Eistert homologation of appropriately protected alpha-amino acids. The affinity of I for five different human somatostatin ...

1999

Increased stability upon heptamerization of the pore-forming toxin aerolysin

Françoise Gisou van der Goot Grunberg

Aerolysin is a bacterial pore-forming toxin that is secreted as an inactive precursor, which is then processed at its COOH terminus and finally forms a circular heptameric ring which inserts into membranes to form a pore. We have analyzed the stability of ...

1999

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