Concept

G banding

Publications associées (14)

Regulation and impact of TERRA R-loops at human telomeres

Telomeres are the nucleoprotein structures found at the ends of linear chromosomes. They ensure that the termini of chromosomes are not inappropriately recognized as sites of DNA damage, and are therefore crucial for genome stability. In spite of the heter ...

EPFL2023

Identification and characterization of proteins that protect human telomeres from fragility

Anna Christina Näger

Difficulties to replicate telomeres - the ends of our chromosomes - can cause telomere shortening andgenome instability. These difficulties are due to the repetitive DNA sequence and distinct structures at telomeresthat challenge the semi-conservative DNA ...

EPFL2022

Tracking the cargo of extracellular symbionts into host tissues with correlated electron microscopy and nanoscale secondary ion mass spectrometry imaging

Anders Meibom, Stéphane Laurent Escrig, Stéphanie Kéren Cohen

Extracellular bacterial symbionts communicate biochemically with their hosts to establish niches that foster the partnership. Using quantitative ion microprobe isotopic imaging (nanoscale secondary ion mass spectrometry [NanoSIMS]), we surveyed localizatio ...

WILEY2020

KAP1 facilitates reinstatement of heterochromatin after DNA replication

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Annamaria Kauzlaric, Andrea Coluccio, Julien Paul André Pontis, Suk Min Jang, Benjamin Rauwel, Geneviève Almouzni

During cell division, maintenance of chromatin features from the parental genome requires their proper establishment on its newly synthetized copy. The loss of epigenetic marks within heterochromatin, typically enriched in repetitive elements, endangers ge ...

2018

Visualizing chemical transport from extracellular symbionts into squid host tissues using NanoSIMS

Stéphanie Kéren Cohen

Chemical communication is the basis of host-microbe interaction. Insights into this communication will provide a deeper understanding of the mechanisms that govern these complex associations, in beneficial as well as pathogenic contexts. In this dissertati ...

EPFL2017

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

Joachim Lingner, Marianna Feretzaki

Telomeres, the heterochromatic structures that protect the ends of the chromosomes, are transcribed into a class of long non-coding RNAs, telomeric repeat-containing RNAs (TERRA), whose transcriptional regulation and functions are not well understood. The ...

2017

Tracking the signaling cargo of extracellular symbionts into host tissues

Anders Meibom, Julia Marie Jeanne Yvonne Bodin, Stéphanie Kéren Cohen

Animal-microbe symbioses are fundamental to animal physiology but how and where bacteria interact with their host, remain largely elusive. The mutualistic association between the Hawaiian bobtail squid, Euprymna scolopes and its luminous bacterium Vibrio f ...

2016

Tracking the signaling cargo of extracellular symbionts into host tissues

Anders Meibom, Julia Marie Jeanne Yvonne Bodin, Stéphanie Kéren Cohen

Animal-microbe symbioses are fundamental to animal physiology but the precise nature of molecular exchange between partners remains largely elusive. The mutualistic association between the Hawaiian bobtail squid, Euprymna scolopes and its luminous bacteriu ...

2016

TERRA biogenesis, turnover and implications for function

Joachim Lingner, Antonio Porro, Sascha Feuerhahn, Andrea Bernardo Panza, Nahid Iglesias

Telomeres are heterochromatic structures at the ends of eukaryotic chromosomes. As other heterochromatin regions, telomeres are transcribed, from the subtelomeric region towards chromosome ends into the long non-coding RNA TERRA. Telomere transcription is ...

Elsevier2010

Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters

Bart Deplancke

Cultivation-independent microbial molecular ecology approaches were used to examine the effects of antibiotic growth promoters on the pig ileal microbiota. Five-week-old barrows were fitted with a simple T-cannula at the distal ileum. Three diets meeting o ...

2003

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