Concept

Lipophilie

Publications associées (32)

Polymeric carriers for therapeutic agents

This thesis deals with development of polymeric carriers for many different therapeutic agents such as immune-suppressant drug (everolimus), nitric oxide (NO), and polynucleotide. Polymeric carriers developed in this project were all synthesized by reversi ...

EPFL2008

Dark curing kinetics of UV printing inks by real-time ATR-FTIR spectroscopy

Eric Jacques Nouzille

In UV-curable printing technology, an ink or a varnish is exposed to the UV-light source within a fraction of a second. Subsequent polymerization therefore proceeds in the dark, referred to as dark curing. Because dark curing can be critical and contribute ...

EPFL2007

Tunable surface nanostructures from Block copolymer self-assembly

Jürgen Brugger, Sivashankar Krishnamoorthy, Harry Heinzelmann, Raphaël Pugin

Nanostructures are known to exhibit novel optical, electrical, and magnetic and many other interesting physical properties and a lot of research has been invested on the synthesis and study of such structures in the recent years. The massive drive towards ...

2005

Functionalized pyrrolidines as alpha-mannosidase inhibitors and growth inhibitors of human glioblastoma and melanoma cells

Pierre Vogel, Sandrine Gerber, Sylvain Favre, Hélène Fiaux

New substituted pyrrolidine-3,4-diol derivatives were prepared from D-(-)- and L-(+)-phenyl glycinol. The influence of the configuration and the substitution of the lateral side chain of these derivatives on the inhibition of 25 commercial glycosidases wer ...

2005

Two-phase partition profiling of drugs and ionisable compounds

Lipophilicity of compounds with therapeutic interest represents one of the most important physicochemical parameters in predicting and interpreting transport processes across biological barriers. This property is commonly measured as a drug | membrane part ...

EPFL2004

Lindane and Technical HCH Residues in Indian Soils and Sediments: A Critical Appraisal

Jean-Paul Schwitzguebel, Sylvie Vullioud-Marcacci

Even at low residue concentrations, persistent organic pollutants (POPs) are of increasing concern all over the world. They include numerous organochlorine pesticides, like hexachlorocyclohexane (HCH), known for its toxicity, lipophilic properties and very ...

2004

Molecular dynamics simulations of MRI-relevant GdIII chelates: direct access to outer-sphere relaxivity

André Merbach, Lothar Helm, Alain Borel

he structure and dynamics of the surrounding water were studied through molecular dynamics (MD) simulations for several GdIII polyaminocarboxylate and polyaminophosphonate complexes in aqueous solution. The radial distribution functions (rdf) show that a f ...

2001

Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention

Pierre Magistretti, Luc Pellerin

Technetium-99m-d,l-hexamethylpropylene amine oxime ((99m)Tc-HMPAO) retention in the brain monitored by single photon emission computed tomography (SPECT) is currently used as a marker of cerebral blood flow. The purported mechanism by which (99m)Tc-HMPAO a ...

2001

Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems

Hubert Girault, Pierre-Alain Carrupt

The objectives of this study were to validate new experimental techniques used to measure the log P of protonated drugs, and to investigate the inter- and intramolecular forces influencing the partitioning behavior of β-blockers in isotropic biphasic solve ...

1999

Structure of Hydrophilic Self-Assembled Monolayers: A Combined Scanning Tunneling Microscopy and Computer Simulation Study

Monolayers of thiols self-assembled on Au (111) can be made hydrophilic by functionalizing the surface with polar endgroups. The authors present scanning tunneling microscopy (STM) images of 2 such hydrophilic monolayers, one terminated by hydroxyl (mercap ...

1994

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