Concept
Physiopathologie
Publications associées (6)
Rational Design of Chemically Controlled Antibodies and Protein Therapeutics
Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Pablo Gainza Cirauqui, Anthony Marchand, Leo Scheller, Lucia Bonati, Stéphane Rosset, Sailan Shui
Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...
2023A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions
Vignayanandam Ravindernath Muddapu
In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale computational model that can replicate the symptoms at the behavioural level by incorporating the key ce ...
FRONTIERS MEDIA SA2022Multidisciplinary Approach to Treat Erectile Dysfunction
Erectile dysfunction (ED) is a widespread disease affecting approximately 20% of men. With a rising incidence due to the global
ageing of the world population, it is estimated that over 322 million patients will be affected in 2025. While not being a lifet ...
EPFL2020Male-killing toxin in a bacterial symbiont of Drosophila
Bruno Lemaitre, Toshiyuki Harumoto
Several lineages of symbiotic bacteria in insects selfishly manipulate host reproduction to spread in a population 1 , often by distorting host sex ratios. Spiroplasma poulsonii2,3 is a helical and motile, Gram-positive symbiotic bacterium that resides in ...
2018Complex Systems in Biomedicine
Alfio Quarteroni, Luca Formaggia
Mathematical modeling of human physiopathology is a tremendously ambitious task. It encompasses the modeling of most diverse compartments such as the cardiovascular, respiratory, skeletal and nervous systems, as well as the mechanical and biochemical inter ...
Springer20063D culture model of the human airway mucosa
Melody Swartz, Alice Anna Tomei
This protocol describes the setup, maintenance and characteristics of a tissue-engineered model of the human bronchial mucosa that can be used for basic physiology and pathophysiology studies. The model includes a well-differentiated epithelium with functi ...
Nature Publishing Group2006