Concept

Facteur neurotrophique dérivé du cerveau

Publications associées (121)

The role of the synthetic enzyme GAD65 in the control of neuronal gamma -aminobutyric acid release

We have studied GABAergic synaptic transmission in retinal ganglion cells and hippocampal pyramidal cells to determine, at a cellular level, what is the effect of the targeted disruption of the gene encoding the synthetic enzyme GAD65 on the synaptic relea ...

National Academy of Sciences1999

Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

About 50% of spinal motoneurons undergo programmed cell death (PCD) after target contact, but little is known about how this process is initiated. Embryonic motoneurons coexpress the death receptor Fas and its ligand FasL at the stage at which PCD is about ...

1999

The Hydrophilic Isoform of Glutamate Decarboxylase, GAD67, Is Targeted to Membranes and Nerve Terminals Independent of Dimerization with the Hydrophobic Membrane-anchored Isoform, GAD65

Steinunn Baekkeskov Hanahan

GAD67, the larger isoform of the γ-aminobutyric acid-synthesizing enzyme glutamic acid decarboxylase, is a hydrophilic soluble molecule, postulated to localize at nerve terminals and membrane compartments by heterodimerization with the smaller membrane-anc ...

American Society for Biochemistry and Molecular Biology1999

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch

In mammals, the first branchial arch (BA1) develops into a number of craniofacial skeletal elements including the jaws and teeth. Outgrowth and patterning of BA1 during early embryogenesis is thought to be controlled by signals from its covering ectoderm. ...

1999

Brain-derived neurotrophic factor stimulates phosphorylation of stathmin in cortical neurons

Pierre Magistretti, Jean-Luc Martin, Jean-René Cardinaux

We have identified by two-dimensional polyacrylamide gel electrophoresis a protein known as stathmin which is phosphorylated in a time- and concentration-dependent manner in response to brain-derived neurotrophic factor (BDNF) in primary cultures of cortic ...

1998

VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones

Pierre Magistretti, Jean-Luc Martin

In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain-derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase-activating polypeptide (PACAP) was analysed by North ...

1998

VIP and PACAP in the CNS: regulators of glial energy metabolism and modulators of glutamatergic signaling

Pierre Magistretti, Jean-Luc Martin, Jean-René Cardinaux

VIP neurons are a homogeneous population of intracortical bipolar cells. They receive excitatory synapses from afferent circuits to the cortex and exert effects on neurons, astrocytes, and capillaries. Effects on the two latter cell types imply that VIP ne ...

The New York Academy of Sciences1998

High potency of the orally-active NMDA-receptor antagonist CGP 40 116 in inhibiting excitatory postsynaptic potentials of rat basolateral amygdala neurones in vitro

Pierre Magistretti, Emilie Pralong

Conventional intracellular recordings were used to monitor postsynaptic potentials of basolateral amygdala neurones (BLA) in brain slices comprising the BLA, the entorhinal cortex (EC) and the hippocampus, in which the EC-BLA connections were preserved. St ...

1998

GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine

Patrick Aebischer

Parkinson's disease (PD) is characterized by the progressive loss of the substantia nigra (SN) dopaminergic neurons projecting to the striatum. Neurotrophic factors may have the potential to prevent or slow down the degenerative process occurring in PD. To ...

1997

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

Patrick Aebischer

We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to promoting the survival of dopaminergic neurons in cultures from embryonic rat ventral mesencephalon,also increases the activity of choline acetyltransferase (C ...

1996

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