Concept
Voie de sauvetage des nucléotides
Publications associées (11)
AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets
AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...
EPFL2022Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease
Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram
Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...
2021Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism
Vassily Hatzimanikatis, Matteo Lunghi, Damien Lionel Nicolas, Anush Chiappino-Pepe, Aarti Krishnan, Dominique Soldati-Favre
To survive and proliferate in diverse host environments with varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have generated and curated a genome-scale metabolic model (iTgo) for the fast-re ...
CELL PRESS2020NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation
Johan Auwerx, Carlos Canto Alvarez, Laurent Mouchiroud, Dongryeol Ryu, Xu Wang, Vincenzo Sorrentino, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani
Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...
Amer Assoc Advancement Science2016Array-based sensing of purine derivatives with fluorescent dyes
Natural and synthetic purine derivatives such as caffeine, theophylline, 6-mercaptopurine and 8-chlorotheophylline are important drugs. Due to the structural similarity of these compounds, it is intrinsically difficult to prepare chemosensors for their sel ...
Royal Soc Chemistry2015