Concept

Ototoxicité

Publications associées (27)

Synthesis, Molecular Structure and Cytotoxicity of Molecular Materials Based on Water Soluble Half-Sandwich Rh(III) and Ir(III) Tetranuclear Metalla-Cycles

Paul Joseph Dyson, Benjamin Samuel Murray

The neutral dinuclear complexes [(eta(5)-C5Me5)(2)Rh-2(mu-dhnq)Cl-2] (1) and [(eta(5)-C5Me5)(2)Ir-2(mu-dhnq)Cl-2] (2) (dhnqH(2) = 5,8-dihydroxy-1,4-naphthoquinone) were obtained from the reaction of (eta(5)-C5Me5)M(mu-Cl)Cl (M = Rh, Ir) with dhnqH(2) ...

2013

DNA Reactivity Profile of trans-Platinum Planar Amine Derivatives

Alexey Nazarov

New trans-platinum planar amines (TPAs) represent a family of platinum-based drugs with cytotoxicity equivalent to that of cisplatin, but with negligible cross-resistance. According to the substitution pattern around the metal center, distinct DNA adducts ...

2011

Fast acquisition of multi-dimensional spectra in solid-state NMR enabled by ultra-fast MAS

David Lyndon Emsley

The advantages offered by ultra-fast (>60 kHz) magic angle spinning (MAS) rotation for the Study of biological samples, notably containing paramagnetic centers are explored. It is shown that optimal conditions for performing solid-state C-13 NMR under 60 k ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2009

Vestibular syndrome: A change in internal spatial representation

Christophe Lopez

The vestibular system contributes to a wide range of functions from reflexes to spatial representation. This paper reviews behavioral, perceptive, and cognitive data that highlight the role of changes in internal spatial representation on the vestibular sy ...

2008

Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes conjugated to ethacrynic acid were prepared as part of a strategy to develop novel glutathione-S-transferase (GST) inhibitors with alternate modes of activity through the organometallic fragment, ultimately to provide targeted rut ...

Wiley-Blackwell2007

Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems

Paul Joseph Dyson, Claire Samantha Allardyce

Proteins from cisplatin treated bacterial cells were partially separated by 1D polyacrylamide gel electrophoresis and analysed by laser ablation inductively coupled plasma mass spectrometry; using peptide fingerprinting methods central to proteomics, the b ...

2001

Simple and complex vestibular responses induced by electrical cortical stimulation of the parietal cortex in humans

Olaf Blanke

The present study reports on a patient undergoing invasive monitoring for intractable epilepsy who experienced different vestibular sensations after electrical cortical stimulation of the inferior parietal lobule at the anterior part of the intraparietal s ...

BMJ Publishing Group2000

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