Concept

Bisphosphonate

Publications associées (20)

Modeling of solids particle diversion to promote uniform growth of multiple hydraulic fractures

Solid particulate additives are sometimes used to promote the uniform growth of multiple hydraulic fractures in horizontal oil and gas wells. The principle is that solid particulates block, accumulate, and form larger porous plugging zones preferentially a ...

ELSEVIER2023

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Osteogenesis imperfecta: from diagnosis and multidisciplinary treatment to future perspectives

Dominique Pioletti, Lee Ann Laurent-Applegate

Osteogenesis imperfecta is an inherited connective tissue disorder with wide phenotypic and molecular heterogen- eity. A common issue associated with the molecular ab- normality is a disturbance in bone matrix synthesis and homeostasis inducing bone fragil ...

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2016

Time course of bone screw fixation following a local delivery of zoledronate in a rat femoral model – a micro-finite element analysis

Dominique Pioletti, Alexandre Terrier, Ulrike Kettenberger, Adeliya Latypova

A good fixation of osteosynthesis implants is crucial for a successful bone healing but often difficult to achieve in osteoporotic patients. One possible solution to this issue is the local delivery of bisphosphonates in direct proximity to the implants, A ...

Elsevier2015

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

Mario Michael Zaiss

Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity ...

Public Library of Science2014

Fracture in complex balsa cores of fiber-reinforced polymer sandwich structures

Thomas Keller, Anastasios Vassilopoulos, Julia De Castro San Roman Fest, Michael Osei-Antwi

Fracture in the complex balsa cores of fiber-reinforced polymer (FRP) sandwich beams was analyzed. The cores were composed of high- and low-density balsa layers separated by a circular adhesive interface or FRP arch. The balsa layers were cut from panels w ...

Elsevier2014

Sensitivity of hip tissues contact evaluation to the methods used for estimating the hip joint center of rotation

Daniel Thalmann, Ronan Boulic, Jérôme Schmid, Ehsan Arbabi

Computer-based simulations of human hip joints generally include investigating contacts happening among soft or hard tissues during hip movement. In many cases, hip movement is approximated as rotation about an estimated hip center. In this paper, we inves ...

Springer-Verlag2012

High hopes for RANKL: will the mouse model live up to its promise?

Cathrin Brisken, Tamara Tanos

The steroid hormones, estrogens and progesterone are key drivers of postnatal breast development and are linked to breast carcinogenesis. Experiments in the mouse mammary gland have revealed that they rely on paracrine factors to relegate their signal loca ...

BioMed Central2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

Fracture and Fatigue of Adhesively-Bonded Fiber-Reinforced Polymer Structural Joints

Ye Zhang

Being good structural replacement for other conventional material, the pultruded glass fiber reinforced polymer (GFRP) profiles are being increasingly used in civil engineering structures. The connection between components is considered the most suspect ar ...

EPFL2010

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