Concept

Cellule pyramidale

Publications associées (195)

In-vivo Bundle-Specific Axon Diameter Distributions Estimation across the Corpus Callosum

Jean-Philippe Thiran, Gabriel Girard, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Maxime Descoteaux

Over the last decade microstructure imaging has become commonly endorsed to estimate quantitative features of neuronal tissue. However, those techniques estimate the microstructure only locally. Microstructure informed tractography was recently proposed to ...

2017

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks

Silvestro Micera

Epilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined ...

Springer Heidelberg2016

Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons

Wulfram Gerstner, Skander Mensi, Christian Antonio Pozzorini, Olivier Richard Hagens

The way in which single neurons transform input into output spike trains has fundamental consequences for network coding. Theories and modeling studies based on standard Integrate-and-Fire models implicitly assume that, in response to increasingly strong i ...

Public Library of Science2016

Assessment of bundle-specific axon diameter distributions using diffusion MRI tractography

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Tim Bjørn Dyrby

The main limitation of diffusion tractography for connectivity studies is that the reconstructed tractograms are not truly quantitative. Microstructure imaging allows the estimation of more quantitative features of the neuronal tissue, such as the axon dia ...

2016

Subunit-selective N-Methyl-D-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation

Michael Kintscher

The maturation of glutamatergic synapses in the CNS is regulated by NMDA receptors (NMDARs) that gradually change from a GluN2B- to a GluN2A-dominated subunit composition during postnatal development. Here we show that NMDARs control the activity of the sm ...

Amer Soc Biochemistry Molecular Biology Inc2016

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Michele Giugliano

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (P ...

Elsevier2016

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

Gioele La Manno

Despite the variety of physiological and target-related functions, little is known regarding the cellular complexity in the sympathetic ganglion. We explored the heterogeneity of mouse stellate and thoracic ganglia and found an unexpected variety of cell t ...

2016

Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition

Ayah Khubieh

The cortex encodes a broad range of inputs. This breadth of operation requires sensitivity to weak inputs yet non-saturating responses to strong inputs. If individual pyramidal neurons were to have a narrow dynamic range, as previously claimed, then stagge ...

Oxford Univ Press Inc2015

Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits

Graham Knott, Anne Alison Jorstad, Yuan Liu, Yan Liu

Synaptic neurotransmission is modified at cortical connections throughout life. Varying the amplitude of the postsynaptic response is one mechanism that generates flexible signaling in neural circuits. The timing of the synaptic response may also play a ro ...

Soc Neuroscience2015

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

Henry Markram, Srikanth Ramaswamy

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

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