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Publications associées (20)

An insular cortex - lateral amygdala network in fear learning

Animals are capable of evaluating sensory cues for possible threats and adapting their behaviours accordingly. Fear learning is an evolutionarily conserved behaviour crucial for animal survival, during which sensory percepts with a negative reinforcing qua ...

EPFL2022

Taming neuronal noise with large networks

Valentin Marc Schmutz

How does reliable computation emerge from networks of noisy neurons? While individual neurons are intrinsically noisy, the collective dynamics of populations of neurons taken as a whole can be almost deterministic, supporting the hypothesis that, in the br ...

EPFL2022

The Role of Hub Neurons in Modulating Cortical Dynamics

Henry Markram, Oren Amsalem, Idan Segev, Eyal Gal, Michael London

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

2021

In situ visualizing the interplay between the separator and potassium dendrite growth by synchrotron X-ray tomography

Yutao Li, Yanan Chen, Kangning Zhao, Chao Yang, Xuchen Wang, Fu Sun

Rechargeable potassium (K) batteries are a promising next-generation technology for low-cost grid scale energy storage applications. Nevertheless, the undesirable interfacial instabilities originating from the interplay between the employed separators and ...

ELSEVIER2021

Design and Synthesis of Gatekeeper Coated Dendritic Silica/Titania Mesoporous Nanoparticles with Sustained and Controlled Drug Release Properties for Targeted Synergetic Chemo-Sonodynamic Therapy

Saba Rezakhani, Samira Malekmohammadi

New dendritic silica/titania mesoporous nanoparticles (DSTNs) loaded with curcumin (CUR) were synthesized and coated with polyethylenimine-folic acid groups (PEI-FA) for an ultrasound (US)-triggered drug release and combined chemo-sonodynamic therapy. The ...

2019

A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

Srikanth Ramaswamy, Vignayanandam Ravindernath Muddapu

Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is ...

2019

Neuronal morphologies: the shapes of thoughts

Lida Kanari

The mammalian brain, one of the most fascinating systems in nature, is a complex biological structure that has kept scientists busy for over a century. Many of the brain's mysteries have been unraveled due to the enormous efforts of the scientific communit ...

EPFL2018

Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal All amacrine cells imaged with multi -photon excitation microscopy

Bas-Jan Zandt

Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming and error-prone and algorith ...

Elsevier2017

At the Edge of Chaos: How Cerebellar Granular Layer Network Dynamics Can Provide the Basis for Temporal Filters

Models of the cerebellar microcircuit often assume that input signals from the mossy-fibers are expanded and recoded to provide a foundation from which the Purkinje cells can synthesize output filters to implement specific input-signal transformations. Det ...

Public Library of Science2015

Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons

Marco Cantoni, Graham Knott, Bohumil Maco

Correlating in vivo imaging of neurons and their synaptic connections with electron microscopy combines dynamic and ultrastructural information. Here we describe a semi-automated technique whereby volumes of brain tissue containing axons and dendrites, pre ...

Public Library of Science2013

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