Publications associées à Antihypertenseur

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger, Patrick Segers

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Arterial remodeling in response to hypertension using a constituent-based model

Nikolaos Stergiopoulos, Alkiviadis Tsamis

Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in ...

2007

Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Nikolaos Stergiopoulos, Paolo Silacci

Hemodynamic forces play a critical role in atherogenesis, as evidenced by the focal pattern of development of atherosclerotic lesions. Whereas disturbed flow in the branches and curved regions of large arteries is proatherogenic, laminar flow in the straig ...

2006

A constitutive formulation of arterial mechanics including vascular smooth muscle tone

Nikolaos Stergiopoulos, Martin Zulliger, Alexander Rachev

A pseudo-strain energy function (pseudo-SEF) describing the biomechanical properties of large conduit arteries under the influence of vascular smooth muscle (VSM) tone is proposed. In contrast to previous models that include the effects of smooth muscle co ...

2004

Synthesis and alpha-mannosidase inhibitory evaluation of (2R,3R,4S)- and (2S,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol derivatives

Pierre Vogel, Sandrine Gerber, Eliazar Rodriguez Garcia

The synthesis of 46 derivatives of (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol is reported (Scheme I and Fig. 3), and their inhibitory activities toward alpha-mannosidases from jack bean (B) and almonds (A) are evaluated (Table). ne most-potent inhibito ...

2003

Biomechanical adaptation of porcine carotid vascular smooth muscle to hypo and hypertension in vitro

Nikolaos Stergiopoulos, Martin Zulliger

Previous research in arterial remodeling in response to changes in blood pressure seldom included both hyper- and hypotension. To compare the effects of low and high pressure on arterial remodeling and vascular smooth muscle tone and performance, we have u ...

2002

Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2

Friedrich Beermann

FGF-2 has been implicated in the cardiac response to hypertrophic stimuli. Angiotensin II (Ang II) contributes to maintain elevated blood pressure in hypertensive individuals and exerts direct trophic effects on cardiac cells. However, the role of FGF-2 in ...

American Society for Clinical Investigation2001

Left ventricular wall stress normalization in chronic pressure-overloaded heart: a mathematical model study

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

It is generally accepted that the left ventricle (LV) hypertrophies (LVH) to normalize systolic wall stress (sigma(s)) in chronic pressure overload. However, LV filling pressure (P(v)) may be elevated as well, supporting the alternative hypothesis of end-d ...

2000

Quantification of the contribution of cardiac and arterial remodeling to hypertension

Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof

The study aim was to quantify the individual and combined contributions of both the arterial system and the heart to systolic blood pressure in hypertension. We assessed the parameters of a heart-arterial model for normotensive control subjects and hyperte ...

2000

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Antihypertenseur

Effects of an aging vascular model on healthy and diseased hearts

Arterial remodeling in response to hypertension using a constituent-based model

Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Peptides derived from sodium caseinate Hydrolysates produced by Lactobacillus helveticus NCC 2765

A constitutive formulation of arterial mechanics including vascular smooth muscle tone

Synthesis and alpha-mannosidase inhibitory evaluation of (2R,3R,4S)- and (2S,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol derivatives

Biomechanical adaptation of porcine carotid vascular smooth muscle to hypo and hypertension in vitro

Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2

Left ventricular wall stress normalization in chronic pressure-overloaded heart: a mathematical model study

Quantification of the contribution of cardiac and arterial remodeling to hypertension

Graph Chatbot

Chattez avec Graph Search

Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Arterial remodeling in response to hypertension using a constituent-based model

Peptides derived from sodium caseinate Hydrolysates produced by Lactobacillus helveticus NCC 2765

A constitutive formulation of arterial mechanics including vascular smooth muscle tone

Effects of an aging vascular model on healthy and diseased hearts

Synthesis and alpha-mannosidase inhibitory evaluation of (2R,3R,4S)- and (2S,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol derivatives

Biomechanical adaptation of porcine carotid vascular smooth muscle to hypo and hypertension in vitro

Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2

Left ventricular wall stress normalization in chronic pressure-overloaded heart: a mathematical model study

Quantification of the contribution of cardiac and arterial remodeling to hypertension