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Mono-N-ethylated alpha-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc)(3). The elaborated one-pot s ...
Several methods are presented for the selective determination of spin-lattice and spin-spin relaxation rates of backbone protons in labeled proteins. The relaxation rates of amide protons in (15)N labeled proteins can be measured by using two-way selective ...
A balanced supplementation method was applied to develop a serum and protein- free medium supporting hybridoma cell batch culture. The aim was to improve systematically the initial formulation of the medium to prevent limitations due to unbalanced concns. ...
Two series of novel, four-arm, star-shaped polypeptides were prepared via the ring-opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride and ε-benzyloxycarbonyl-L-lysine N-carboxyanhydride with a tetra-amino-substituted perylene fluorophore as ...
FMOC-L-Leucine (F-L-Leu) is a chemically distinct PPARgamma ligand. Two molecules of F-L-Leu bind to the ligand binding domain of a single PPARgamma molecule, making its mode of receptor interaction distinct from that of other nuclear receptor ligands. F-L ...
Math. description of metabolic systems allows the calcn. of the expected responses of metab. to genetic modifications and the identifications of the most promising targets for metabolic engineering. Metabolic control anal. (MCA) provides such a description ...
Sterols and cholesterol in particular are lipids that have been studied exhaustively in view of their vital role in diverse cellular functions. Recently, it has been recognized that cholesterol is not only an essential component for the formation of membra ...
The Nef protein of human immunodeficiency virus type 1 (HIV-1) promotes virion infectivity through mechanisms that are yet ill defined. Some Nef is incorporated into particles, where it is cleaved by the viral protease between amino acids 57 and 58. The fu ...
Putative intersubunit electrostatic interactions between charged amino acids on the surfaces of the dimer interfaces of leucine zippers (g-e' ion pairs) have been implicated as determinants of dimerization specificity. To evaluate the importance of these i ...
We report on a study of B 0 → D(*)0 π+π- decays using 29.1 fb-1 of e+e- annihilation data recorded at the γ(4S) resonance with the Belle detector at the KEKB storage ring. Making no assumptions about the intermediate mechanism, the branching fractions for ...
