Concept
Valine
Publications associées (20)
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
Vassily Hatzimanikatis, Maria Masid Barcon, Ming Yang
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and metastatic clonally-related ...
NATURE PORTFOLIO2022GCN2 adapts protein synthesis to scavenging-dependent growth
Pancreatic cancer cells with limited access to free amino acids can grow by scavenging extracellular protein. In a murine model of pancreatic cancer, we performed a genome-wide CRISPR screen for genes required for scavenging-dependent growth. The screen id ...
2022Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode
The anodic oxidation of polar amino acids (L-serine, L-threonine, L-asparagine, and L-glutamine) in aqueous electrolyte on smooth platinum electrode was carried out by cyclic voltammetry coupled to electrochemical quartz crystal microbalance (EQCM). pH (zw ...
Elsevier2017High levels of ammonia do not raise fine particle pH sufficiently to yield nitrogen oxide-dominated sulfate production
High levels of ammonia (NH3) have been suggested to elevate ambient particle pH levels to near neutral acidity (pH = 7), a condition that promotes rapid SO2 oxidation by NO2 to form aerosol sulfate concentration consistent with "London fog" levels. This po ...
Nature Publishing Group2017Multilaser Conformer-Selective Spectroscopy of Cold Biomolecular Ions in the Gas Phase
Proteins and even small peptides play crucial role in almost any biological. Biological activity and functionality of these building blocks of life are determined not only by their primary structure, but also by their 3D orientation â secondary, tertiary ...
EPFL2017Novel inhibitors of the enzyme activated factor xii (fxiia)
Christian Heinis, Jonas Alfred Karl Wilbs, Vanessa Baeriswyl, Simon Jan Middendorp
The present invention relates to a bicyclic inhibitor of the coagulation enzyme activated factor XII (FXIIa) comprising or consisting of the peptide (X1)(X2)(X3)n(X4)(X5)(X6)m(X7)(X9)l(X10)(X11)(X12)(X13)(X14)k(X15)(X16), wherein (X1) is present or absent ...
2016SRT1720 improves survival and healthspan of obese mice
Johan Auwerx, Carlos Canto Alvarez
Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate ...
2011Enantioselective Aza-Morita-Baylis-Hillman Reaction Using Aliphatic alpha -Amidosulfones as Imine Surrogates
The bifunctional catalyst 6'-deoxy-6'-acylamino-beta -isocupreidine served both as a base to trigger the in situ generation of N-sulfonylimine from readily available alpha -amidosulfones and as a chiral nucleophile to initiate the enantioselective aza-Mori ...
Wiley-Blackwell2010