Concept

Corneal opacity

Publications associées (9)

A machine-learning algorithm correctly classifies cortical evoked potentials from both visual stimulation and electrical stimulation of the optic nerve

Diego Ghezzi, Eleonora Borda, Vivien Gaillet, Elodie Geneviève Zollinger

Objective. Optic nerve's intraneural stimulation is an emerging neuroprosthetic approach to provide artificial vision to totally blind patients. An open question is the possibility to evoke individual non-overlapping phosphenes via selective intraneural op ...

IOP PUBLISHING LTD2021

Virtual reality simulation of epiretinal stimulation highlights the relevance of the visual angle in prosthetic vision

Diego Ghezzi, Enrico Migliorini, Jacob Thomas Thorn

Objective. Retinal prostheses hold the potential to restore artificial vision in blind patients suffering from outer retinal dystrophies. The optimal number, density and coverage of the electrodes that a retinal prosthesis should have to provide adequate a ...

2020

Comparison Between the eyeWatch Device and the Ahmed Valve in Refractory Glaucoma

Nikolaos Stergiopoulos, André Mermoud, Sylvain Roy, Adan Villamarin, Stéphane Bigler, Constantinos Stergiopulos

Purpose: To assess the efficacy and safety of a glaucoma procedure to control intraocular pressure (IOP) using the adjustable eyeWatch glaucoma drainage device compared with Ahmed glaucoma valve (AGV) in refractory glaucoma. Patients and Methods: Monocentr ...

LIPPINCOTT WILLIAMS & WILKINS2020

In vivo electrical stimulation of the optic nerve and hybrid computational model for neuroprosthetic applications

Silvestro Micera, Diego Ghezzi, Samuel Charles Antoine Gilliéron, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet

Blindness affects millions of people worldwide, dramatically decreasing their quality of life. Retinal dystrophies, such as age related macular degeneration and Retinitis Pigmentosa, which are leading causes of blindness in industrialized countries, curren ...

2018

Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus

Keratoconus, a common inherited ocular disorder resulting in progressive corneal thinning, is the leading indication for corneal transplantation in the developed world. Genome-wide association studies have identified common SNPs 100 kb upstream of ZNF469 s ...

Oxford University Press2014

LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis

Yann Barrandon, Andrea Zaffalon

Corneal integrity and transparency are indispensable for good vision. Cornea homeostasis is entirely dependent upon corneal stem cells, which are required for complex wound-healing processes that restore corneal integrity following epithelial damage. Here, ...

American Society for Clinical Investigation2014

Sutureless ocular surface reconstruction

Basile Salmon

Corneal diseases account for eight million blind people worldwide, making up to 10% of all causes of blindness. As 80% of the information is collected by our senses, blindness is a very invalidating condition which lowers greatly patients’ quality of life. ...

2010

Oligopotent stem cells are distributed throughout the mammalian ocular surface

Yann Barrandon, Ariane Rochat, Georges Abou Jaoudé

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty- five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal trans ...

2008

Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism

Freddy Radtke, Yann Barrandon

Integrity and preservation of a transparent cornea are essential for good vision. The corneal epithelium is stratified and nonkeratinized and is maintained and repaired by corneal stem cells. Here we demonstrate that Notch1 signaling is essential for cell ...

2007

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