Concept
Hépatite alcoolique aiguë
Publications associées (20)
Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression
The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
EPFL2022Defined matrices for epithelial organoid culture and disease modelling
Advances in our understanding of the biology of stem cells and their niches have provided the necessary foundation to create in vitro complex self-organizing three-dimensional (3D) structures called organoids. While organoids represent a highly promising n ...
EPFL2021Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis
Kristina Schoonjans, Jian Liu, Bhoomika Mathur
Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases. Methods: We performed high-throughput sequencing of ...
2020Natural iron ligands promote a metal-based oxidation mechanism for the Fenton reaction in water environments
César Pulgarin, Stefanos Giannakis, Giulio Farinelli
The Fenton reaction is an effective advanced oxidation process occurring in nature and applied in engineering processes toward the degradation of harmful substances, including contaminants of emerging concern. The traditional Fenton application can be rema ...
ELSEVIER2020PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
Johan Auwerx, Dongryeol Ryu, Wei Wang, Karim Laurent Gariani, Zhou Zhou
Background & Aims: Mitochondria) dysfunction, oxidative stress, inflammation, and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play ...
Elsevier Science Bv2017Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia
Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good unders ...
Natl Acad Sciences2017Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice
Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic steatohep ...
Public Library of Science2016Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP
Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...
Informa Healthcare2014The Receptor TGR5 Protects the Liver From Bile Acid Overload During Liver Regeneration in Mice
Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both ...
Wiley-Blackwell2013Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes
The proprotein convertases (PCs) furin, PC5/6, and PACE4 exhibit unique and/or complementary functions. Their knockout (KO) in mice resulted in strong and specific phenotypes demonstrating that, in vivo, these PCs are unique and essential during developmen ...
American Society for Biochemistry and Molecular Biology2013