Concept

Targeted drug delivery

Publications associées (75)

Quantitative Analysis of Scanning Tunneling Microscopy Images of Mixed-Ligand-Functionalized Nanoparticles

Francesco Stellacci, Quy Ong Khac, Javier Reguera Gomez, Christoph Renner

Ligand-protected gold nanoparticles exhibit large local curvatures, features rapidly varying over small scales, and chemical heterogeneity. Their imaging by scanning tunneling microscopy (STM) can, in principle, provide direct information on the architectu ...

American Chemical Society2013

Assessment of protein binding with magnetic microrobots in fluid

Mahmut Selman Sakar

For applications such as targeting therapeutic nanocarriers to specific tissues, as well as for the more general problem of assessing binding affinity between proteins, it is important to discover tools which may be used for both micromanipulation as well ...

2013

Nanoparticle actuated hollow drug delivery vehicles

Esther Amstad

The trend towards personalized medicine and the long-standing wish to reduce drug consumption and unwanted side effects have been the driving force behind research on drug delivery vehicles that control localization, timing and dose of released cargo. Cont ...

2012

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

Jeffrey Alan Hubbell, Susan Thomas

The assessment of macrophage response to nanoparticles is a central component in the evaluation of new nanoparticle designs for future in vivo application. This work investigates which feature, nanoparticle size or charge, is more predictive of non-specifi ...

2012

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

Li Tang

Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate superior performance in vitro and in vivo. However, it i ...

American Chemical Society2012

Efficient polymer passivation of ligand-stripped nanocrystal surfaces

Raffaella Buonsanti

Water-dispersible, polymer-wrapped nanocrystals are highly sought after for use in biol. and chem., from nanomedicine to catalysis. The hydrophobicity of their native ligand shell, however, is a significant barrier to their aq. transfer as single particles ...

2012

Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles

Anu Kodiyan

Poly(ethylene) glycol is commonly used to stabilize gold nanoparticles (GNPs). In this study, we evaluated the ability of cysteine-functionalized alginate-derived polymers to both provide colloidal stability to GNPs and avoid recognition and sequestration ...

2012

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Alice Anna Tomei, Karen Dane, Jackson Eby

By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm are efficiently transported through ly ...

Elsevier2011

Ordering Surfaces on the Nanoscale: Implications for Protein Adsorption

Francesco Stellacci

Monolayer-protected metal nanoparticles (MPMNs) are a newly discovered class of nanoparticles with an ordered, striped domain structure that can be readily manipulated by altering the ratio of the hydrophobic to hydrophilic ligands. This property makes the ...

2011

X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors

Giorgio Margaritondo

The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma - optical emission spectroscopy (ICP-OES), transmission electron microsc ...

Elsevier2011

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