Publications associées à Nucléase à doigt de zinc

TAL Effectors Specificity Stems from Negative Discrimination

Matteo Dal Peraro, Marco Stenta, Basile Isidore Martin Wicky

Transcription Activator-Like (TAL) effectors are DNA-binding proteins secreted by phytopathogenic bacteria that interfere with native cellular functions by binding to plant DNA promoters. The key element of their architecture is a domain of tandem-repeats ...

Public Library of Science2013

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton, Michele Cascella, Hisham Ben Hamidane, Anne Thérèse Sigstam

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

2012

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

Didier Trono, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Anna Claire Groner

The study of chromatin and its regulators is key to understanding and manipulating transcription. We previously exploited the Krüppel-associated box (KRAB) transcriptional repressor domain, present in hundreds of vertebrate-specific zinc finger proteins, t ...

2012

TERRA Promotes Telomere Shortening through Exonuclease 1-Mediated Resection of Chromosome Ends

Joachim Lingner, Verena Pfeiffer

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. ...

Public Library of Science2012

ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites

Giovanna Ambrosini, Christian Iseli, Philipp Bucher

Background: Zinc Finger Nucleases (ZFNs) are man-made restriction enzymes useful for manipulating genomes by cleaving target DNA sequences. ZFNs allow therapeutic gene correction or creation of genetically modified model organisms. ZFN specificity is not a ...

BioMed Central2011

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Paul Joseph Dyson, Olivier Pierre Zava

The reaction of copper(II) chloride or copper(II) acetate with 6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo-[3,2-d][1]benzazepine (HL1), 9-bromo-6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (HL2), N-9-bromo-7,12 ...

2010

Simple and efficient transgenesis with meganuclease constructs in zebrafish.

Andrew Charles Oates, Daniele Soroldoni

In the past, microinjection of plasmid DNA into early embryos represented the state of the art to generate transgenic zebrafish. However, this approach suffers significant drawbacks (mosaic distribution of the injected transgene, late transgene integration ...

2009

The extracellular nuclease Dns and its role in natural transformation of Vibrio cholerae

Melanie Blokesch

Free extracellular DNA is abundant in many aquatic environments. While much of this DNA will be degraded by nucleases secreted by the surrounding microbial community, some is available as transforming material that can be taken up by naturally competent ba ...

American Society for Microbiology2008

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Nucléase à doigt de zinc

TAL Effectors Specificity Stems from Negative Discrimination

UV radiation induces genome-mediated, site-specific cleavage in viral protein

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

TERRA Promotes Telomere Shortening through Exonuclease 1-Mediated Resection of Chromosome Ends

ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Simple and efficient transgenesis with meganuclease constructs in zebrafish.

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

The extracellular nuclease Dns and its role in natural transformation of Vibrio cholerae

Graph Chatbot

Chattez avec Graph Search

TAL Effectors Specificity Stems from Negative Discrimination

TERRA Promotes Telomere Shortening through Exonuclease 1-Mediated Resection of Chromosome Ends

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

UV radiation induces genome-mediated, site-specific cleavage in viral protein

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Simple and efficient transgenesis with meganuclease constructs in zebrafish.

The extracellular nuclease Dns and its role in natural transformation of Vibrio cholerae