Concept

Maladie osseuse de Paget

Publications associées (42)

The role of MYC in bone and in the hematopoietic stem cell niche

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

Bone reactions to controlled loading of endosseous implants: a pilot study

John Botsis, Joël Cugnoni

Objectives: To validate an experimental setup designed to apply load onto bone tissue using osseointegrated implants in a rabbit model. Specifically, (1) to design an apparatus capable of generating controlled forces, (2) to assess implant placement, maint ...

Wiley-Blackwell2008

High-speed photography of compressed human trabecular bone correlates whitening to microscopic damage

Georg Fantner, Blake William Erickson

Mechanical testing of trabecular bone is mainly motivated by the huge impact of osteoporosis in post-menopausal women and the aged in society in terms of social and health care costs. Trabecular bone loss and impairment of its mechanical properties reduce ...

2007

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

Vincent Stadelmann

The transcription factor Sox4 is vital for fetal development, as Sox4–/– homozygotes die in utero. Sox4 mRNA is expressed in the early embryonic growth plate and is regulated by parathyroid hormone, but its function in bone modeling/remodeling is unknown. ...

2007

High-speed photography of the development of microdamage in trabecular bone during compression

Georg Fantner, Blake William Erickson

The mechanical properties of healthy and diseased bone tissue were extensively studied in mechanical tests. Most of this research was motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged ...

2006

Delay of intracortical bone remodelling following a stress change: a theoretical and experimental study

Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo

BACKGROUND: A theoretical model and an experimental setup were specifically designed to identify and determine the delay of the cortical bone response (restricted to mineralization and demineralization) to a stress change. METHODS: The in vivo experiment c ...

2005

High-speed photography of human trabecular bone during compression

Georg Fantner, Blake William Erickson

The mechanical properties of healthy and diseased bone tissue are extensively studied in mechanical tests. Most of this research is motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged. ...

2005

Detraining effects on the mechanical properties and morphology of rat tibiae

Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Pierre-François Leyvraz

To study bone adaptation to detraining in growing rats, nine weeks-old immature female Wistar rats (n=110) were subjected to treadmill running programs (30 or 60 minutes-a-day) for up to 15 weeks, followed by unrestricted cage activities for the subsequent ...

2004

Orthopedic implants used as drug delivery systems

Bastian Peter

Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...

EPFL2004

Can the increase of bone mineral density following bisphosphonates treatments be explained by biomechanical considerations?

Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo

OBJECTIVE: We hypothesized that bone mineral density increase following bisphosphonates treatments may be explained by the influence of the drug on the mechanical bone remodeling parameters. BACKGROUND: Patients treated with bisphosphonates continuously in ...

2004

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