Concept
Hypothyroïdie
Publications associées (17)
Cryo-EM structure of native human thyroglobulin
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...
2022Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is st ...
AMER SOC MICROBIOLOGY2022Neural correlates of visual backward masking in psychosis
Michael Herzog, Christine Mohr, Maya Roinishvili, Ophélie Gladys Favrod
In visual backward masking (VBM), a target is followed by a mask, which deteriorates performance on the target. Schizophrenia and first episodes patients show strong behavioral deficits, reflected in strongly reduced amplitudes of the EEG as compared to co ...
2017Associations between Daily Walking and Subclinical Health Markers in a Swiss City
Vincent Kaufmann, Emmanuel Pierre Jean Ravalet, Idris Guessous, Derek Pierre Christie
Every year, the Health Bus (Bus Santé) enables a representative sample of around 1000 members of the non-institutionalised adult population of Geneva, Switzerland, to undergo a health evaluation including physical measurements, blood tests and questionnair ...
2017Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes
Understanding mol. recognition is of fundamental importance in applications such as therapeutics, chem. catalysis and sensor design. The most common recognition motifs involve biol. macromols. such as antibodies and aptamers. The key to biorecognition cons ...
2013Detection and treatment of subclinical tuberculosis
Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research that ...
Elsevier2012Measured binding coefficients for iodine and ruthenium dyes; implications for recombination in dye sensitised solar cells
Shaik Mohammed Zakeeruddin, Robin Humphry-Baker, Filippo de Angelis, Xiong Li
We have measured the binding coefficients of iodine to three dyes used in Dye Sensitised Solar Cells (DSSCs). Binding coefficients are quantified via the effect of iodine binding on the UV-vis spectrum of the dye. From iodine titration curves of dye sensit ...
Royal Society of Chemistry2012Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa
A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relativ ...
2012Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
Autoimmune diabetes mellitus in humans is characterized by immunological destruction of pancreatic beta islet cells. We investigated the circumstances under which CD8(+) T cells specific for pancreatic beta-islet antigens induce disease in mice expressing ...
2005Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/-) mice
We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional beta cells, linke ...
2004