Concept

Noréthandrolone

Norethandrolone, sold under the brand names Nilevar and Pronabol among others, is an androgen and anabolic steroid (AAS) medication which has been used to promote muscle growth and to treat severe burns, physical trauma, and aplastic anemia but has mostly been discontinued. It is still available for use in France however. It is taken by mouth. Side effects of norethandrolone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It can also cause estrogenic effects like fluid retention, breast tenderness, and breast enlargement in men and liver damage. The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong anabolic effects relative to its androgenic effects. The drug also has strong progestogenic effects. Norethandrolone was discovered in 1953 and was introduced for medical use in 1956. It was the first AAS with a favorable separation of anabolic and androgenic effect to be marketed. The drug was mostly withdrawn in the 1980s due to concerns of liver damage. In addition to its medical use, norethandrolone has been used to improve physique and performance. The drug is a controlled substance in many countries and so non-medical use is generally illicit. Norethandrolone has been used in the treatment of muscle wasting, patients with severe burns, after severe trauma, and for certain forms of aplastic anemia among other indications. Side effects of norethandrolone include virilization among others. It has estrogenic effects and can cause gynecomastia and fluid retention. As with all 17α-alkylated AAS, long-term use of norethandrolone in high doses may result in hepatotoxicity including elevated liver enzymes and cirrhosis. Norethandrolone is an androgen and anabolic steroid and hence is an agonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone.

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EPFL2022
Concepts associés (12)
Noréthistérone
La noréthistérone est un progestatif de synthèse utilisé dans certaines pilules combinées et certaines pilules progestatives, et pour retarder les menstruations. La noréthistérone n'est pas encore distribuée en France, mais est depuis plusieurs années disponible sur ordonnance dans de nombreux pays européens comme l'Allemagne, l'Italie, la Belgique, ainsi qu'aux États-Unis. L'effet permet de retenir la muqueuse utérine dans l'utérus.
Estrogen (medication)
An estrogen (E) is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy, and as part of feminizing hormone therapy for transgender women. They can also be used in the treatment of hormone-sensitive cancers like breast cancer and prostate cancer and for various other indications. Estrogens are used alone or in combination with progestogens. They are available in a wide variety of formulations and for use by many different routes of administration.
Normethandrone
Normethandrone, also known as methylestrenolone or methylnortestosterone and sold under the brand name Metalutin among others, is a progestin and androgen/anabolic steroid (AAS) medication which is used in combination with an estrogen in the treatment of amenorrhea and menopausal symptoms in women. It is taken by mouth. Side effects of normethandrone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It can also cause liver damage.
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