Concept

Epidermolysis bullosa

Publications associées (4)

Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome

There is currently no approved treatment for Netherton syndrome, which is a severe, genetic skin disease characterized by chronic inflammation and excessive peeling of the skin. Even though the molecular disease mechanism has been assigned to the unopposed ...

EPFL2019

A single epidermal stem cell strategy for safe ex vivo gene therapy

Graham Knott, Jacques Rougemont, Yann Barrandon, Ariane Rochat, Andrea Zaffalon, Nicolas Grasset, Stéphanie Danièle Hélène Droz-Georget, Sara Benmohammed, Emmanuelle Savioz-Dayer, Alessandra Recchia

There is a widespread agreement from patient and professional organisations alike that the safety of stem cell therapeutics is of paramount importance, particularly for ex vivo autologous gene therapy. Yet current technology makes it difficult to thoroughl ...

Wiley Open Access2015

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

To examine the consequences of repressing beta-catenin/Lef1 signalling in mouse epidermis, we expressed a DeltaNLef1 transgene, which lacks the beta-catenin binding site, under the control of the keratin 14 promoter. No skin abnormalities were detected bef ...

2002

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

Didier Trono, Romain Zufferey

The murine embryonal stem (ES) cell virus (MESV) can express transgenes from the long terminal repeat (LTR) promoter/enhancer in undifferentiated ES cells, but expression is turned off upon differentiation to embryoid bodies (EBs) and hematopoietic cells i ...

2000

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