Publications associées à Patch-sequencing

Cortical cell assemblies and their underlying connectivity: an in silico study

Michael Reimann, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

2024

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

Carl Petersen, Sylvain Crochet, Aurélie Pala, Taro Kiritani, Célia Roxane Gasselin

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

PUBLIC LIBRARY SCIENCE2023

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

Nicolas Grégoire Maïno

Micro- nano-electrodes have demonstrated superior performances in measuring attenuated intracellular action potentials from electrogenic cell cultures compared to traditional multi-electrode arrays. Yet, the understanding of the critical electrode features ...

EPFL2023

A universal workflow for creation, validation and generalization of detailed neuronal models

Henry Markram, Srikanth Ramaswamy, Mustafa Anil Tuncel, Werner Alfons Hilda Van Geit, Alexis Arnaudon, Christian Andreas Rössert, Maria Reva, Tanguy Pierre Louis Damart, Darshan Mandge

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Cambridge2023

Printed Iontophoretic‐Integrated Wearable Microfluidic Sweat‐Sensing Patch for On‐Demand Point‐Of‐Care Sweat Analysis

Danick Briand, Silvia Demuru, Brince Paul Kunnel

In recent years, wearable epidermal sweat sensors have received extensive attention owing to their great potential to provide personalized information on the health status of individuals at the molecular level. For on‐demand medical analysis of sweat in se ...

Wiley2021

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt, Steven Petrou

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

Benoît Xavier Emmanuel Desbiolles

Micro-nanotechnology based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recordings of excitable cells. However, electrode geometries alone have failed to produce a cell-electrode interface that is sufficiently ...

EPFL2020

Data driven building of realistic neuron model using IBEA and CMA evolution strategies

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart

Recently the building of large neuronal circuits from realistic neuron models has gained traction. This bottom-up approach relies on the accurate description of the primitive elements composing the brain such as neurons and astrocytes, that are then aggreg ...

ACM2020

Micropipette calibration by differential pressure measurements

Philippe Renaud, David Vincent Bonzon

The pipetting of small volumes, typically ranging between a few and one thousand microliters (mu l), is widely used in many laboratories and essentially relies on air displacement to aspirate and dispense the liquid contained in a small plastic tip. ...

IOP PUBLISHING LTD2019

Clamp-Tapering Increases the Quality Factor of Stressed Nanobeams

Tobias Kippenberg, Alberto Beccari, Dalziel Joseph Wilson, Nils Johan Engelsen, Sergey Fedorov, Ryan Daniel Schilling, Amir Hossein Ghadimi

Stressed nanomechanical resonators are known to have exceptionally high quality factors (Q) due to the dilution of intrinsic dissipation by stress. Typically, the amount of dissipation dilution and thus the resonator Q is limited by the high mode curvature ...

AMER CHEMICAL SOC2019