Concept
Metal–halogen exchange
Publications associées (61)
Methods for high-throughput synthesis and screening of peptide libraries
Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...
EPFL2024Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds
Macrocycles have raised much interest in the pharmaceutical industry due to their ability to bind challenging targets while often still being able to cross membranes to reach intracellular proteins. However, the development of macrocyclic ligands to new di ...
EPFL2023Structure and Reactivity of N-Heterocyclic Alkynyl Hypervalent Iodine Reagents
Rosario Scopelliti, Jérôme Waser, Farzaneh Fadaei Tirani, Matthew Wodrich, Eliott Hugo Joran Le Du
Ethynylbenziodoxol(on)e (EBX) cyclic hypervalent iodine reagents have become popular reagents for the alkynylation of radicals and nucleophiles, but only offer limited possibilities for further structure and reactivity fine-tuning. Herein, the synthesis of ...
2021Remote C(sp 3 )−H Arylation and Vinylation of N ‐Alkoxypyridinium Salts to δ‐Aryl and δ‐Vinyl Alcohols
Qian Wang, Jieping Zhu, Xu Bao
The reaction of readily available and benchstable N-alkoxypyridinium salts with arylboronic and vinylboronic acids afforded d-aryl and d-vinyl alcohols, respectively, in the presence of fac-Ir(ppy)3 and Cu(OTf)2 dual catalysts. The reaction takes place thr ...
2019Remote C(sp(3))-H Arylation and Vinylation of N-Alkoxypyridinium Salts to delta-Aryl and delta-Vinyl Alcohols
Qian Wang, Jieping Zhu, Xu Bao
The reaction of readily available and bench-stable N-alkoxypyridinium salts with arylboronic and vinylboronic acids afforded delta-aryl and delta-vinyl alcohols, respectively, in the presence of fac-Ir(ppy)(3) and Cu(OTf)(2) dual catalysts. The reaction ta ...
WILEY-V C H VERLAG GMBH2019On-surface transmetalation of metalloporphyrins
Klaus Kern, Jan Gui-Hyon Dreiser, Pietro Gambardella, Markus Etzkorn, Claudius Morchutt, Sebastian Stepanow, Patrick Eduard Alexa
Increasing the complexity of 2D metal-organic networks has led to the fabrication of structures with interesting magnetic and catalytic properties. However, increasing complexity by providing different coordination environments for different metal types im ...
2018Decarboxylative C(sp3)–N cross-coupling via synergetic photoredox and copper catalysis
Xile Hu, Runze Mao, Jonathan Balon, Adrian Frey
Amines are a quintessential moiety in bioactive molecules, pharmaceuticals and organic materials. Transition-metal-catalysed C–N coupling of aryl electrophiles has been established as a powerful and reliable method for amine synthesis. However, the analogo ...
2018High-pressure NMR spectroscopy: An in situ tool to study tin-catalyzed synthesis of organic carbonates from carbon dioxide and alcohols. Part 2 [1]
Gabor Laurenczy, Andrew Francis Dalebrook
Dialkoxide diorganotin(IV) complexes are known to readily react with carbon dioxide under pressure and they are considered as suitable catalyst precursor models for the direct synthesis of organic carbonates. To gain a better understanding of CO2 insertion ...
Elsevier2015Implementation of cell-free biological networks at steady state
Sebastian Maerkl, Henrike Marie Niederholtmeyer, Viktoria Stepanova
Living cells maintain a steady state of biochemical reaction rates by exchanging energy and matter with the environment. These exchanges usually do not occur in in vitro systems, which consequently go to chemical equilibrium. This in turn has severely cons ...
National Academy of Sciences2013Intricacies of Describing Weak Interactions involving Halogen Atoms within Density Functional Theory
Ursula Röthlisberger, Ivano Tavernelli
In this work we assess the performance of different dispersion-corrected DFT approaches (M06, M06-2X, DFT-D3 and DCACP) in reproducing high-level wave function based benchmark calculations on the weakly bound halogen dimers (X2)2 and X2-Ar (for X=F,Cl,Br,I ...
Amer Chemical Soc2013