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A major limitation of current lentiviral vectors (LVs) is their inability to govern efficient gene transfer into quiescent cells, such as human CD34+ cells that reside into G0 phase of the cell cycle and that are highly enriched in hematopoietic stem cells ...
BACKGROUND: New lymphatic growth may contribute to tumor metastasis. Activation of vascular endothelial growth factor receptor 3 (VEGFR-3) by its ligands VEGF-C and -D is necessary for embryonic and tumor lymphangiogenesis. However, the exact role of VEGFR ...
In this contribution we present the development of three microfabricated devices for the study of neuronal and cellular networks. Together, these devices form an attractive toolbox, which is useful to stimulate and record signals of both electrical and che ...
Alternative cathode materials were investigated for application to high voltage lithium ion batteries. Manganese based materials were considered due to the low cost and environmentally sustainable impact. Layer-structured oxide and phospho-olivine material ...
Background: The microfabricated impedance spectroscopy flow cytometer used in this study permits rapid dielectric characterization of a cell population with a simple microfluidic channel. Impedance measurements over a wide frequency range provide informati ...
There are many elements in plasma that can act as surrogate markers of the physiological well-being of a mouse, thus making the collection of blood and plasma a general technique with many applications in mouse phenotyping. For example, the presence of cer ...
Traditional snakes, or active contours, are planar parametric curves. Their parameters are determined by optimizing the weighted sum of three energy terms: one depending on the data (typically on the integral of its gradient under the curve, or on its inte ...
This work presents label-free separation of cells in an on-chip flow cytometer based on impedance spectroscopy. The amplitude, opacity, and phase information can be used for discrimination depending on the cell types. Red blood cells, ghosts, and fixed cel ...
We present a new approach for biomass assessment in cell culture using a disposable microcentrifuge tube. The specially designed tube is fitted with an upper chamber for sample loading and a lower 5 microL capillary for cell collection during centrifugatio ...
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of ...