Concept

Placenta

Publications associées (37)

Species-specific regulation of XIST by the JPX/FTX orthologs

X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved concom ...

OXFORD UNIV PRESS2023

Prenatal auditory experience and its sequelae

Lukas Vogelsang, Marin Vogelsang

Towards the end of the second trimester of gestation, a human fetus is able to register environmental sounds. This in utero auditory experience is characterized by comprising strongly low-pass-filtered versions of sounds from the external world. Here, we p ...

WILEY2022

From adult dentate gyrus neurogenesis to pattern separation

Olivia Gozel

For a few decades, adult dentate gyrus neurogenesis has been widely recognized by the neuroscience community as an intriguing phenomenon. Two observations are particularly puzzling. At the cellular level, the switch from excitation to inhibition of the GAB ...

EPFL2019

A KRABsody for Embryo-Placental Development

Didier Trono

Many of the hundreds of KRAB zinc finger proteins encoded by human and mouse are involved in taming the transcriptional regulatory potential of transposable elements. Reporting recently in Science, Yang et al. (2017) reveal that one murine family member, Z ...

2017

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Evaristo Jose Planet Letschert, Julien Léonard Duc, Sonia Verp, Andrea Coluccio, Alberto De Iaco

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

Brain network characterization of high-risk preterm-born school-age children

Jean-Philippe Thiran, Alessandra Griffa, Elda Fischi Gomez, François Lazeyras

Higher risk for long-term cognitive and behavioral impairments is one of the hallmarks of extreme prematurity (EP) and pregnancy-associated fetal adverse conditions such as intrauterine growth restriction (IUGR). While neurodevelopmental delay and abnormal ...

Elsevier Sci Ltd2016

Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction

Yohan Van de Looij, Maxime Olivier Baud

Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms link ...

Wiley-Blackwell2016

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

Lionel André Maurizi

BACKGROUND: Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and invitro studies have shown that nan ...

Nat Inst of Environ Health Sciences / The National Institute of Environmental Health Sciences (NIEHS)2015

Engineered cell instructive matrices for fetal membrane healing

Martin Ehrbar

Iatrogenic preterm prelabour rupture of fetal membranes (iPPROM) occurs in 6-45% of the cases after fetoscopic procedures, posing a significant threat to fetal survival and well-being. The number of diagnostic and therapeutic prenatal interventions availab ...

Elsevier Sci Ltd2015

Conjugates containing sequences from placenta growth factor and their use as components of biomaterials and in medicine

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, an ...

2015

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