Publications associées à Stratified columnar epithelium

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

EPFL2024

Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium

Cathrin Brisken, Stéphanie Cagnet

17 beta-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ER alpha. ER alpha acts as a transcription factor but also elicits rapid signaling through a fraction of ER alpha ...

2020

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Dalya Ataca, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

Oestrogen receptor alpha AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Cathrin Brisken, Ayyakkannu Ayyanan, Georgios Sflomos, Dalya Ataca, Valentina Scabia, Stéphanie Cagnet, Patrik Aouad

Oestrogen receptor alpha (ER alpha) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), ter ...

Nature Publishing Group2018

Exploring the potency of normal and pathological human thymic epithelial cells

Tiphaine Mélodie Chantal Arlabosse

Thymic epithelial cells (TECs) are organised in a unique 3D network that is critical for the development of efficient and self-tolerant T-cells. We report for the first time that the human thymus of all ages, even old and involuted, contains a significant ...

EPFL2017

A balancing act between stratification and EMT in cultured human thymic epithelial cells

Matteo Pluchinotta

The thymus is the primary organ for T cell differentiation and maturation. Its stroma forms a characteristic sponge-like 3D structure mainly composed of thymic epithelial cells. Despite of this unconventional epithelial architecture, TECs express markers a ...

EPFL2016

Ice-covered Lake Onega: effects of radiation on convection and internal waves

Alfred Johny Wüest, Damien Bouffard, Natacha Tofield-Pasche

Early-spring under-ice convection in the Petrozavodsk Bay of Lake Onega (Russia) was investigated as part of an interdisciplinary research project conducted during March 2015. Measurements performed using a thermistor chain and vertical profiling sensors w ...

Springer Verlag2016

Endocrine hormones and local signals during the development of the mouse mammary gland

Cathrin Brisken, Dalya Ataca

Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...

Wiley-Blackwell2015

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Cathrin Brisken, Jacques Rougemont, Ayyakkannu Ayyanan, Marian Caikovski, Duje Buric, Renuga Devi Rajaram

Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...

Wiley-Blackwell2015