Concept

Cytochrome P450

Publications associées (32)

Reactivity and Biological Properties of a Series of Cytotoxic PtI2(amine)(2) Complexes, Either cis or trans Configured

Six diiodido-diamine platinum(II) complexes, either cis or trans configured, were prepared, differing only in the nature of the amine ligand (isopropylamine, dimethylamine, or methylamine), and their antiproliferative properties were evaluated against a pa ...

2012

Accumulation of pollutants and plant wellness : Bottleneck or key to successful phytoremediation ?

Jean-Paul Schwitzguebel

Because plants are static and live in a competitive and sometimes hostile environment, they have evolved mechanisms that protect them from abiotic and biotic stress. These mechanisms include detoxification and sequestration of xenobiotic compounds and of h ...

2011

Integrated biosensing for diagnosis and therapy

Giovanni De Micheli

Monitoring human metabolism is of crucial importance for personalized medicine. Many metabolic diseases can be treated by controlling various endogenous metabolites (e.g., glucose, lactate, cholesterol, etc.). Similarly, measuring the metabolism of exogeno ...

2011

Accumulation and detoxification of sulfonated aromatic compounds from dye and textile industries by different plant species

Jean-Paul Schwitzguebel

Sulfonated anthraquinones are precursors of a large family of synthetic dyes and pigments, recalcitrant to biodegradation and thus not eliminated by classical wastewater treatments. In the development of a phytotreatment to remove sulfonated aromatic compo ...

2010

Multiplexing pH and Temperature in a Molecular Biosensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Michele Daniel Torre, Daniela De Venuto

Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same ...

2010

Differential Regulation by Heat Stress of Novel Cytochrome P450 Genes from the Dinoflagellate Symbionts of Reef-Building Corals

Exposure to heat stress has been recognized as one of the major factors leading to the breakdown of the coral-alga symbiosis and coral bleaching. Here, we describe the presence of three new cytochrome P450 (CYP) genes from the reef-building coral endosymbi ...

American Society for Microbiology2010

Plant accumulation of pollutants versus plant wellness: insoluble conundrum or key to a successful green clean-up?

Jean-Paul Schwitzguebel

2010

P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini

Nowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to inves ...

2010

Design of a CNFET Array for Sensing and Control in P450 based Biochips for multiple drug detection

Giovanni De Micheli, Sandro Carrara, Shashi Kanth Bobba

Bio-detection specially dedicated to distributed diagnostics is emerging as a quite important application for Nanobioelectronics. Bio-detection is required to be highly sensitive in order to succeed in sensing small amount of bio-markers in patient’s blood ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2010

The role of cytochromes P450 and peroxidases in the detoxification of sulphonated anthraquinones by rhubarb and common sorrel plants cultivated under hydroponic conditions

Jean-Paul Schwitzguebel

Background, aim and scope Sulphonated anthraquinones are precursors of many synthetic dyes and pigments, recalcitrant to biodegradation and thus not eliminated by classical wastewater treatments. In the development of a phytotreatment to remove sulphonated ...

Springer-Verlag2009

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